A FULLY INTEGRATED CMOS SENSOR FOR PICO-CURRENT MEASUREMENT ON SOLID-STATE NANOPORE DEVICES

Jungsuk Kim, Kenneth D. Pedrotti, William B. Dunbar

2012

Abstract

In this paper, an integrated high-sensitivity patch-clamp sensor is proposed to measure the ultra-low current variation of a solid-state nanopore device. This sensor amplifier consists of three stages: 1) a headstage, 2) a difference amplifier and 3) a unity-gain buffer. For the headstage, a resistive-feedback transimpedance amplifier is employed to convert the small current to a readable voltage. The addition of a programmable gain to the second-stage difference amplifier allows the maximum gain to be increased to 168dBΩ. This sensor is fabricated in a 0.35m CMOS process and is tested with an 80nm-diameter solid-state nanopore. We present a detailed circuit analysis for the low-noise patch-clamp design and its noise measurement result in this paper.

References

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Paper Citation

in Harvard Style

Kim J., Pedrotti K. and Dunbar W. (2012). A FULLY INTEGRATED CMOS SENSOR FOR PICO-CURRENT MEASUREMENT ON SOLID-STATE NANOPORE DEVICES . In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012) ISBN 978-989-8425-91-1, pages 27-31. DOI: 10.5220/0003732000270031

in Bibtex Style

@conference{biodevices12,
author={Jungsuk Kim and Kenneth D. Pedrotti and William B. Dunbar},
title={A FULLY INTEGRATED CMOS SENSOR FOR PICO-CURRENT MEASUREMENT ON SOLID-STATE NANOPORE DEVICES},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012)},
year={2012},
pages={27-31},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003732000270031},
isbn={978-989-8425-91-1},
}

in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012)
TI - A FULLY INTEGRATED CMOS SENSOR FOR PICO-CURRENT MEASUREMENT ON SOLID-STATE NANOPORE DEVICES
SN - 978-989-8425-91-1
AU - Kim J.
AU - Pedrotti K.
AU - Dunbar W.
PY - 2012
SP - 27
EP - 31
DO - 10.5220/0003732000270031