A Novel and Low Cost Acoustic based Probe for Local Pulse Wave Velocity Estimation - Experimental Characterization and in-Vivo Feasibility

H. C. Pereira, J. Maldonado, T. Pereira, M. Contente, V. Almeida, T. Pereira, J. B. Simões, J. Cardoso, C. Correia

2013

Abstract

The use of local pulse wave velocity (PWV) as an independent risk factor for cardiovascular events and as a marker of atherosclerosis has been gained clinical relevance over the years. A novel acoustic double headed probe for non-invasive measurement of the local PWV is presented in this paper. The PWV is assessed in one single location and involves the determination of time delay between the signals acquired simultaneously by two acoustic sensors, placed ≈11 mm apart. Several tests were performed in special purposes test bench systems in order to characterize the acoustic probe (AP) regarding the existence of crosstalk between the transducers, repeatability, waveform analysis and also its time resolution. Results demonstrate the effectiveness of the AP in acquiring repeatedly the same waveform, with the possibility to measure higher PWV (14 m/s), with a relative error less than 5%, when using two uncoupled APs. In-vivo acquisitions were also carried out with the AP in the carotid artery of 17 healthy volunteers with the intention of local PWV and other hemodynamic parameters estimation, such as left ventricular ejection time (LVET). For the total of subjects’ sample, the obtained mean carotid PWV was 2.96±1.08 m/s and the LVET mean value was 288.59±21.42 ms.

References

  1. Almeida, V., Pereira, T., Borges, E., Figueiras, E., Cardoso, J., Correia, C., Pereira, H. C., Malaquias, J. L. and Simões, J. B. 2009. Synthesized cardiac waveform in the evaluation of augmentation index algorithms. In Proceedings of BIOSIGNALS 2010, Valencia, Spain.
  2. Borlotti, A., Khir, A. W., Rietzschel, E. R., De Buyzere, M. L., Vermeersch, S. & Segers, P. 2012. Noninvasive determination of local pulse wave velocity and wave intensity: changes with age and gender in the carotid and femoral arteries of healthy human. J Appl Physiol, 113, 727-35.
  3. Boutouyrie, P., Brie, M., Collin, C., Vermeesch, S. and Pannier, B. 2009. Assessment of pulse wave velocity. Artery Research, 3, 3-8.
  4. Gamble, G., Zorn, J., Sanders, G., Macmahon, S. & Sharpe, N. 1994. Estimation of arterial stiffness, compliance, and distensibility from M-mode ultrasound measurements of the common carotid artery. Stroke, 25, 11-6.
  5. Gaszner, B., Lenkey, Z., Illyes, M., Sarszegi, Z., Horvath, I. G., Magyari, B., Molnar, F., Konyi, A. & Cziraki, A. 2012. Comparison of aortic and carotid arterial stiffness parameters in patients with verified coronary artery disease. Clin Cardiol, 35, 26-31.
  6. Hasegawa, M., Rodbard, D. & Kinoshita, Y. 1991. Timing of the carotid arterial sounds in normal adult men: measurement of left ventricular ejection, pre-ejection period and pulse transmission time. Cardiology, 78, 138-49.
  7. Hermeling, E., Reesink, K. D., Reneman, R. S. & Hoeks, A. P. 2007. Measurement of local pulse wave velocity: effects of signal processing on precision. Ultrasound Med Biol, 33, 774-81.
  8. Laurent, S., Boutouyrie, P., Asmar, R., Gautier, I., Laloux, B., Guize, L., Ducimetiere, P. & Benetos, A. 2001. Aortic stiffness is an independent predictor of allcause and cardiovascular mortality in hypertensive patients. Hypertension, 37, 1236-41.
  9. Laurent, S., Cockcroft, J., Van Bortel, L., Boutouyrie, P., Giannattasio, C., Hayoz, D., Pannier, B., Vlachopoulos, C., Wilkinson, I., Struijker-Boudier, H. & European Network for Non-Invasive Investigation of Large, A. 2006. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J, 27, 2588-605.
  10. Laurent, S., Katsahian, S., Fassot, C., Tropeano, A., Gautier, I., Laloux, B. and Boutouyrie, P. 2003. Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke, 34, 1203-1206.
  11. Maldonado, J., Pereira, T., Polonia, J., Silva, J. A., Morais, J., Marques, M. & Participants in The, E. P. 2011. Arterial stiffness predicts cardiovascular outcome in a low-to-moderate cardiovascular risk population: the EDIVA (Estudo de DIstensibilidade VAscular) project. J Hypertens, 29, 669-75.
  12. Mancia, G., De Backer, G., Dominiczak, et al., Management of Arterial Hypertension of the European Society Of, H. & European Society Of, C. 2007. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens, 25, 1105-87.
  13. Meaume, S., Rudnichi, A., Lynch, A., Bussy, C., Sebban, C., Benetos, A. & Safar, M. E. 2001. Aortic pulse wave velocity as a marker of cardiovascular disease in subjects over 70 years old. J Hypertens, 19, 871-7.
  14. Murgo, J. P., Westerhof, N., Giolma, J. P. & Altobelli, S. A. 1980. Aortic input impedance in normal man: relationship to pressure wave forms. Circulation, 62, 105-16.
  15. Pannier, B. M., Avolio, A. P., Hoeks, A., Mancia, G. & Takazawa, K. 2002. Methods and devices for measuring arterial compliance in humans. Am J Hypertens, 15, 743-53.
  16. Pereira, H. C., Cardoso, J. M., Almeida, V. G., Pereira, T., Borges, E., Figueiras, E., Ferreira, L. R., Simões, J., Correia, C. 2009. Programmable testbench for hemodynamic studies. IFMBE Proceedings 25/IV 1460ff.
  17. Pereira, H. C., Pereira, T., Almeida, V., Borges, E., Figueiras, E., Simoes, J. B., Malaquias, J. L., Cardoso, J. M. & Correia, C. M. 2010. Characterization of a double probe for local pulse wave velocity assessment. Physiol Meas, 31, 1449-65.
  18. Pereira, H. C., Basílio, J. B., Malaquias, J., Pereira, T., Almeida, V., Borges, E., Figueiras, E., Cardoso, J. and Correia C. 2011. Double Headed Probe for Local Pulse Wave Velocity Estimation - A new device for hemodynamic parameters assessment. In Proceedings of BIOSIGNALS 2011, Rome, Italy.
  19. Rabben, S. I., Stergiopulos, N., Hellevik, L. R., Smiseth, O. A., Slordahl, S., Urheim, S. & Angelsen, B. 2004. An ultrasound-based method for determining pulse wave velocity in superficial arteries. J Biomech, 37, 1615-22.
  20. Segers, P., Kips, J., Trachet, B., Swillens, A., Vermeersch, S., Mahieu, D., Rietzchel, E., Buyzere, M. and Bortel, L. 2009. Limitations and pitfalls of non-invasive measurement of arterial pressure wave reflections and pulse wave velocity. Artery Research, 3, 79-88.
  21. Shoji, T., Emoto, M., Shinohara, K., Kakiya, R., Tsujimoto, Y., Kishimoto, H., Ishimura, E., Tabata, T. & Nishizawa, Y. 2001. Diabetes mellitus, aortic stiffness, and cardiovascular mortality in end-stage renal disease. J Am Soc Nephrol, 12, 2117-24.
  22. Willems, J. L., Roelandt, J., De Geest, H., Kesteloot, H. & Joossens, J. V. 1970. The left ventricular ejection time in elderly subjects. Circulation, 42, 37-42.
Download


Paper Citation


in Harvard Style

Pereira H., Maldonado J., Pereira T., Contente M., Almeida V., Pereira T., Simões J., Cardoso J. and Correia C. (2013). A Novel and Low Cost Acoustic based Probe for Local Pulse Wave Velocity Estimation - Experimental Characterization and in-Vivo Feasibility . In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2013) ISBN 978-989-8565-34-1, pages 78-88. DOI: 10.5220/0004251900780088


in Bibtex Style

@conference{biodevices13,
author={H. C. Pereira and J. Maldonado and T. Pereira and M. Contente and V. Almeida and T. Pereira and J. B. Simões and J. Cardoso and C. Correia},
title={A Novel and Low Cost Acoustic based Probe for Local Pulse Wave Velocity Estimation - Experimental Characterization and in-Vivo Feasibility},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2013)},
year={2013},
pages={78-88},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004251900780088},
isbn={978-989-8565-34-1},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2013)
TI - A Novel and Low Cost Acoustic based Probe for Local Pulse Wave Velocity Estimation - Experimental Characterization and in-Vivo Feasibility
SN - 978-989-8565-34-1
AU - Pereira H.
AU - Maldonado J.
AU - Pereira T.
AU - Contente M.
AU - Almeida V.
AU - Pereira T.
AU - Simões J.
AU - Cardoso J.
AU - Correia C.
PY - 2013
SP - 78
EP - 88
DO - 10.5220/0004251900780088