A Label-free Detection of Carcinoembryonic Antigen (CEA) using Micromechanical Biosensors

Meisam Omidi, Mohammadmehdi Choolaei, F. Haghiralsadat, M. Azhdari, N. Davodi Moghadam, F. Yazdian

2014

Abstract

We have used arrays of micromechanical biosensors to detect carcinoembryonic antigen (CEA), a protein biomarker associated with various cancers such as colorectal, lung, breast, pancreatic, and bladder cancer. The sensing principle is based on the surface stress changes induced by antigen–antibody interaction on the micromechanical membrane (MM) surfaces. MM consists of a membrane suspended by four piezoresistive sensing components. The isotropic surface stress on the membrane results in a uniaxial stress in each sensing component, which efficiently improves the sensitivity. According to the experiments, it was revealed that MMs have surface stress sensitivities in the order of 2 (mJ/m). This matter allows them to detect CEA concentrations as low as 500 pg mL-1 or 3 pM. This indicates the fact that the self-sensing MM approach is beneficial for pathological tests.

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Paper Citation


in Harvard Style

Omidi M., Choolaei M., Haghiralsadat F., Azhdari M., Davodi Moghadam N. and Yazdian F. (2014). A Label-free Detection of Carcinoembryonic Antigen (CEA) using Micromechanical Biosensors . In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2014) ISBN 978-989-758-013-0, pages 134-139. DOI: 10.5220/0004800701340139


in Bibtex Style

@conference{biodevices14,
author={Meisam Omidi and Mohammadmehdi Choolaei and F. Haghiralsadat and M. Azhdari and N. Davodi Moghadam and F. Yazdian},
title={A Label-free Detection of Carcinoembryonic Antigen (CEA) using Micromechanical Biosensors},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2014)},
year={2014},
pages={134-139},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004800701340139},
isbn={978-989-758-013-0},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2014)
TI - A Label-free Detection of Carcinoembryonic Antigen (CEA) using Micromechanical Biosensors
SN - 978-989-758-013-0
AU - Omidi M.
AU - Choolaei M.
AU - Haghiralsadat F.
AU - Azhdari M.
AU - Davodi Moghadam N.
AU - Yazdian F.
PY - 2014
SP - 134
EP - 139
DO - 10.5220/0004800701340139