New Maskless Lithography System for Fabricating Biodevices using Light-Emitting Diodes and Squared Optical Fibers
Jun Watanabe, Jun-ya Iwasaki, Toshiyuki Horiuchi
2016
Abstract
A new low-cost lithography system convenient for fabricating biodevices was developed. Using the new system, various patterns of cell arrays, chamber arrays, flow paths of micro-fluidic devices, and others were easily printed without preparing any reticles or masks. In the system, light-emitting diodes (LEDs) were used as exposure sources and squared optical fibers arrayed in a 10×10 matrix were used as the combination of a secondary light source and a reticle. Light rays emitted from each LED were individually led to each fiber, and bright or dark of each LED was assigned by a personal computer. As a result, it became possible to print arbitrary patterns without preparing any reticles or masks. In addition to the ordinary patterning using various lightening maps of LEDs and their stitching, scan exposure was also tried. When bright images of optical fiber ends were scanned on a resist film by moving the wafer stage, long patterns appropriate for micro fluidic paths were very smoothly formed.
References
- Arnandis, C. T., Morais, S., Tortajada, G. L. A., Puchades, R., Maquieira, A., Berganza, J., and Olabarria, G., 2012. Detection of food-borne pathogens with DNA arrays on disk. Talanta, 101, pp. 405-412.
- Boero, C., Casulli, A. M., Olivo, J., Foglia, L., Orso, E., Mazza, M., Carrara, S., and Micheli, D. G., 2014. Design, development, and validation of an in-situ biosensor array for metabolite monitoring of cell cultures. Biosensors and Bioelectronics, 61, pp. 251- 259.
- Bianchi, E., Molteni, R., Pardi, R., and Dubini, G., 2013. Microfluidics for in vitro biomimetic shear stressdependent leukocyte adhesion assays. Journal of Biomechanics, 46, pp. 276-283.
- Choi, H. J., Ogunniyi, O, A., Du, M., Du, M., Kretschmann, M., Eberhardt, J., and Love, C, J., 2010. Development and Optimization of a Process for Automated Recovery of Single Cells Identified by Microengraving. Biotechnology progress, 26, pp. 888-895.
- Gach, C. P., Attayek, J. P., Whittlesey, L. R., Yeh, J. J., and Allbritton, L. N., 2014. Micropallet arrays for the capture, isolation and culture of circulating tumor cells from whole blood of mice engrafted with primary human pancreatic adenocarcinoma. Biosensors and Bioelectronics, 54, pp. 476-483.
- Ilyas, A., Asghar, W., Kim, Y., and Iqbal, M. S., 2014. Parallel recognition of cancer cells using an addressable array of solid-state micropores. Biosensors and Bioelectronics, 62, pp. 343-349.
- Kim, J., Hilton, P. J., Yang, K., Pei, R., Stojanovic, M., and Lin, Q., 2013. Nucleic acid isolation and enrichment on a microchip. Sensors and Actuators, A 195, pp. 183- 190.
- Lei, F. K., Wu, M., Hsu, C., and Chen, Y., 2014. Real-time and non-invasive impedimetric monitoring of cell proliferation and chemosensitivity in a perfusion 3D cell culture microfluidic chip. Biosensors and Bioelectronics, 51, pp. 16-21.
- Li, S., Floriano, N. P., Christodoulides, N., Fozdar, Y. D., Shao, D., Ali, F. M., Dharshan, P., Mohanty, S., Neikirk, D., McDevitt, T. J., and Chen, S., 2005. Disposable polydimethylsiloxane/silicon hybrid chips for protein detection. Biosensors and Bioelectronics, 21, pp. 574- 580.
- Lyu, S., Chen, W., and Hsieh, W., 2014. Measuring transport properties of cell membranes by a PDMS microfluidic device with controllability over changing rate of extracellular solution. Sensors and Actuators, B 197, pp. 28-34.
- Malainou, A., Petrou, S. P., Kakabakos, E. S., Gogolides, E., and Tserepi, A., 2012. Creating highly dense and uniform protein and DNA microarrays through photolithography and plasma modification of glass substrates. Biosensors and Bioelectronics, 34, pp. 273- 281.
- Moraes, C., Wang, G., Sun, Y., and Simmons, A. C., 2010. A microfabricated platform for high-throughput unconfined compression of micropatterned biomaterial arrays. Biomaterials, 31, pp. 577-584.
- Negrete, D. O., and Cerrina, F., 2008. Step-and-scan maskless lithography for ultra large scale DNA chips. Microelectronic Engineering, 85, pp. 834-837.
- Schmidt, R., Cook, A. E., Kastelic, D., Taussig, J. M., and Stoevesandt, O., 2013. Optimised 'on demand' protein arraying from DNA by cell free expression with the 'DNA to Protein Array' (DAPA) technology. Journal of protemics, 88, pp. 141-148.
- Tanii, T., Hosaka, T., Miyake, T., Zhang, G., Zako, T., Funatsua, T., and Ohdomari, I., 2004. Preferential immobilization of biomolecules on silicon microstructure array by means of electron beam lithography on organosilane self-assembled monolayer resist. Applied Surface Science, 234, pp. 102-106.
- Wang, T. C., and Hu, C. Y., 2010. Mixing of Liquids Using Obstacles in Y-Type Microchannels. Tamkang Journal of Science and Engineering, 13, No. 4, pp. 385-394.
- Wang, H., Bao, N., and Lu, C., 2008. A microfluidic cell array with individually addressable culture chambers. Biosensors and Bioelectronics, 24, pp. 613-617.
Paper Citation
in Harvard Style
Watanabe J., Iwasaki J. and Horiuchi T. (2016). New Maskless Lithography System for Fabricating Biodevices using Light-Emitting Diodes and Squared Optical Fibers . In Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2016) ISBN 978-989-758-170-0, pages 203-208. DOI: 10.5220/0005757802030208
in Bibtex Style
@conference{biodevices16,
author={Jun Watanabe and Jun-ya Iwasaki and Toshiyuki Horiuchi},
title={New Maskless Lithography System for Fabricating Biodevices using Light-Emitting Diodes and Squared Optical Fibers},
booktitle={Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2016)},
year={2016},
pages={203-208},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005757802030208},
isbn={978-989-758-170-0},
}
in EndNote Style
TY - CONF
JO - Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2016)
TI - New Maskless Lithography System for Fabricating Biodevices using Light-Emitting Diodes and Squared Optical Fibers
SN - 978-989-758-170-0
AU - Watanabe J.
AU - Iwasaki J.
AU - Horiuchi T.
PY - 2016
SP - 203
EP - 208
DO - 10.5220/0005757802030208