Optogentics and Optrode Technology to Brain Function Manupulation

Mohammad Ismail Zibaii, Leila Dargahi, Abdolaziz Ronaghi, Farshad Abedzadeh, Sareh Pandamoz, Saied Salehi, Zahra Fatahi, Abbas Haghparast, Hamid Latifi

2016

Abstract

Optogenetics comprises a growing family of related techniques for the optical interrogation and control of excitable cells. Combining genetic targeting with light delivery systems makes it possible to drive or silence subpopulations of neurons and the related behaviours, with a high spatiotemporal precision. Since optical manipulation is fast, selective, and minimally invasive, it provides distinct advantages over traditional electrical means or pharmacological approaches for cell perturbation. Here we showed in anesthetized rat that optogenetic stimulation of nucleus accumbens (NAc) neurons increased neural activation. We labelled a population of neurons activated with channelrhodopsin-2 (ChR2) and later optically stimulated these neurons by using an optrode and recorded spontaneous action potentials from the one neuron.

Paper Citation

in Harvard Style

Zibaii M., Dargahi L., Ronaghi A., Abedzadeh F., Pandamoz S., Salehi S., Fatahi Z., Haghparast A. and Latifi H. (2016). Optogentics and Optrode Technology to Brain Function Manupulation.In Proceedings of the 4th International Conference on Photonics, Optics and Laser Technology - Volume 1: OSENS, (PHOTOPTICS 2016) ISBN 978-989-758-174-8, pages 321-332. DOI: 10.5220/0005842303210332

in Bibtex Style

@conference{osens16,
author={Mohammad Ismail Zibaii and Leila Dargahi and Abdolaziz Ronaghi and Farshad Abedzadeh and Sareh Pandamoz and Saied Salehi and Zahra Fatahi and Abbas Haghparast and Hamid Latifi},
title={Optogentics and Optrode Technology to Brain Function Manupulation},
booktitle={Proceedings of the 4th International Conference on Photonics, Optics and Laser Technology - Volume 1: OSENS, (PHOTOPTICS 2016)},
year={2016},
pages={321-332},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005842303210332},
isbn={978-989-758-174-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Photonics, Optics and Laser Technology - Volume 1: OSENS, (PHOTOPTICS 2016)
TI - Optogentics and Optrode Technology to Brain Function Manupulation
SN - 978-989-758-174-8
AU - Zibaii M.
AU - Dargahi L.
AU - Ronaghi A.
AU - Abedzadeh F.
AU - Pandamoz S.
AU - Salehi S.
AU - Fatahi Z.
AU - Haghparast A.
AU - Latifi H.
PY - 2016
SP - 321
EP - 332
DO - 10.5220/0005842303210332