Entorhinal Grid Cells May Facilitate Pattern Separation in the Hippocampus

Jochen Kerdels, Gabriele Peters

2017

Abstract

The dentate gyrus (DG) in the hippocampus of the mammalian brain is known to exhibit strong pattern separation. However, how this pattern separation arises in the DG is not well understood. Here we offer a novel hypothesis regarding this problem by demonstrating that pattern separation can already be performed by entorhinal grid cells, which are located just one synapse upstream of the DG. For our simulations we utilize a recently introduced grid cell model that interprets the behavior of grid cells as just one instance of a general information processing scheme. The obtained results challenge the established view that pattern separation occurs primarily in the DG, and they uncover a common misconception regarding the specificity of ensemble activity in grid cells.

Paper Citation

in Harvard Style

Kerdels J. and Peters G. (2017). Entorhinal Grid Cells May Facilitate Pattern Separation in the Hippocampus.In Proceedings of the 9th International Joint Conference on Computational Intelligence - Volume 1: IJCCI, ISBN 978-989-758-274-5, pages 141-148. DOI: 10.5220/0006514601410148

in Bibtex Style

@conference{ijcci17,
author={Jochen Kerdels and Gabriele Peters},
title={Entorhinal Grid Cells May Facilitate Pattern Separation in the Hippocampus},
booktitle={Proceedings of the 9th International Joint Conference on Computational Intelligence - Volume 1: IJCCI,},
year={2017},
pages={141-148},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006514601410148},
isbn={978-989-758-274-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 9th International Joint Conference on Computational Intelligence - Volume 1: IJCCI,
TI - Entorhinal Grid Cells May Facilitate Pattern Separation in the Hippocampus
SN - 978-989-758-274-5
AU - Kerdels J.
AU - Peters G.
PY - 2017
SP - 141
EP - 148
DO - 10.5220/0006514601410148