Antihyperglycemic and Pancreatic Protective Effect of Squalene in Streptozotocin-induced Diabetic Rat

Tri Widyawati, Siti Syarifah, Muhammad Ichwan, Dwi Rita Anggraini, Arlinda Sari Wahyuni

2018

Abstract

Squalene (Sq), is one compound that reported found in antidiabetic plant (Syzygium polyanthum Wight Walp leaf). The aim of this study was to evaluate its antihyperglycemic activity and potential pancreactic protective effect in streptozotocin-induced diabetic rats (SDR). Twenty Wistar rats (male, 180-230 g) were divided into four groups (n=5) and treated once daily for 14 days p.o. Group I (Sq 160 mg/kg), Group II (metformin (M) 500 mg/kg), Group IV (diabetic control (DC) distilled water 10 ml/kg) and Group III (normal control (NC) distilled water 10 ml/kg). Blood glucose level (BGL) and a histological study of the pancreas were performed. As compared to DC, SQ showed significant reduction (p<0.05-0.01) at day6-day14. Interestingly, histopathological assessment showed the restoration of the STZ-induced pancreatic islet cells damage. The present study concluded that Sq have antihyperglycemic activity and pancreatic protective effect.

Paper Citation

in Harvard Style

Widyawati T., Syarifah S., Ichwan M., Anggraini D. and Wahyuni A. (2018). Antihyperglycemic and Pancreatic Protective Effect of Squalene in Streptozotocin-induced Diabetic Rat. In Proceedings of the 3rd International Conference of Computer, Environment, Agriculture, Social Science, Health Science, Engineering and Technology - Volume 1: ICEST, ISBN 978-989-758-496-1, pages 483-486. DOI: 10.5220/0010045204830486

in Bibtex Style

@conference{icest18,
author={Tri Widyawati and Siti Syarifah and Muhammad Ichwan and Dwi Rita Anggraini and Arlinda Sari Wahyuni},
title={Antihyperglycemic and Pancreatic Protective Effect of Squalene in Streptozotocin-induced Diabetic Rat},
booktitle={Proceedings of the 3rd International Conference of Computer, Environment, Agriculture, Social Science, Health Science, Engineering and Technology - Volume 1: ICEST,},
year={2018},
pages={483-486},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010045204830486},
isbn={978-989-758-496-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 3rd International Conference of Computer, Environment, Agriculture, Social Science, Health Science, Engineering and Technology - Volume 1: ICEST,
TI - Antihyperglycemic and Pancreatic Protective Effect of Squalene in Streptozotocin-induced Diabetic Rat
SN - 978-989-758-496-1
AU - Widyawati T.
AU - Syarifah S.
AU - Ichwan M.
AU - Anggraini D.
AU - Wahyuni A.
PY - 2018
SP - 483
EP - 486
DO - 10.5220/0010045204830486