Optimization of Polymer and Cross-linker Combination on the Formation of Pectin Film Containing Metformin Hydrochloride

Mariadi, Bayu Eko Prasetyo, Yade Metri Permata

2018

Abstract

Pectin has been developed as an edible film in drug delivery systems, however pectin has some disadvantages such as rapid drug release, low mechanical strength, and low drug infusion efficiency. The purpose of this study was to optimize the polymer and cross-linker combination on the formation of pectin film containing metformin hydrochloride. The films were prepared using a single or combination of polymer as a matrix and glycerin as a plasticizer. The homogenous mixture of pectin mucilage, alginate mucilage, hydroxyl-propyl methylcellulose (HPMC) mucilage, ethyl-cellulose, glycerin, and metformin hydrochloride was flattened on an object glass (2 cm x 5 cm) and then allowed to dry at room temperature. The all formula were evaluated the capability of forming the membrane or film and elasticity properties. The pectin, alginate, HPMC, and ethyl-cellulose polymer in single or two polymer combination cannot form a film with the addition of metformin hydrochloride. The combination of three polymers of pectin, alginate, and ethyl-cellulose can form a finer, smoother surface, more elastic, rolled and folded membrane/film. The combination of three polymers of pectin, alginate, ethyl-cellulose and the addition of cross-linkers to a combination of pectin, alginate, HPMC provides an optimal film for Drug Delivery System.

Paper Citation

in Harvard Style

Mariadi., Prasetyo B. and Permata Y. (2018). Optimization of Polymer and Cross-linker Combination on the Formation of Pectin Film Containing Metformin Hydrochloride.In Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR, ISBN 978-989-758-449-7, pages 845-851. DOI: 10.5220/0010093608450851

in Bibtex Style

@conference{icosteerr18,
author={Mariadi and Bayu Eko Prasetyo and Yade Metri Permata},
title={Optimization of Polymer and Cross-linker Combination on the Formation of Pectin Film Containing Metformin Hydrochloride},
booktitle={Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,},
year={2018},
pages={845-851},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010093608450851},
isbn={978-989-758-449-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches - Volume 1: ICOSTEERR,
TI - Optimization of Polymer and Cross-linker Combination on the Formation of Pectin Film Containing Metformin Hydrochloride
SN - 978-989-758-449-7
AU - Mariadi.
AU - Prasetyo B.
AU - Permata Y.
PY - 2018
SP - 845
EP - 851
DO - 10.5220/0010093608450851