Real-time Low SNR Signal Processing for Nanoparticle Analysis with Deep Neural Networks

Jan Eric Lenssen, Anas Toma, Albert Seebold, Victoria Shpacovitch, Pascal Libuschewski, Frank Weichert, Jian-Jia Chen, Roland Hergenröder

2018

Abstract

In this work, we improve several steps of our PLASMON ASSISTED MICROSCOPY OF NANO-SIZED OBJECTS (PAMONO) sensor data processing pipeline through application of deep neural networks. The PAMONObiosensor is a mobile nanoparticle sensor utilizing SURFACE PLASMON RESONANCE (SPR) imaging for quantification and analysis of nanoparticles in liquid or air samples. Characteristics of PAMONO sensor data are spatiotemporal blob-like structures with very low SIGNAL-TO-NOISE RATIO (SNR), which indicate particle bindings and can be automatically analyzed with image processing methods. We propose and evaluate deep neural network architectures for spatiotemporal detection, time-series analysis and classification. We compare them to traditional methods like frequency domain or polygon shape features classified by a Random Forest classifier. It is shown that the application of deep learning enables our data processing pipeline to automatically detect and quantify 80 nm polystyrene particles and pushes the limits in blob detection with very low SNRs below one. In addition, we present benchmarks and show that real-time processing is achievable on consumer level desktop GRAPHICS PROCESSING UNITs (GPUs).

Paper Citation

in Harvard Style

Lenssen J., Toma A., Seebold A., Shpacovitch V., Libuschewski P., Weichert F., Chen J. and Hergenröder R. (2018). Real-time Low SNR Signal Processing for Nanoparticle Analysis with Deep Neural Networks. In Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - Volume 4: BIOSIGNALS; ISBN 978-989-758-279-0, SciTePress, pages 36-47. DOI: 10.5220/0006596400360047

in Bibtex Style

@conference{biosignals18,
author={Jan Eric Lenssen and Anas Toma and Albert Seebold and Victoria Shpacovitch and Pascal Libuschewski and Frank Weichert and Jian-Jia Chen and Roland Hergenröder},
title={Real-time Low SNR Signal Processing for Nanoparticle Analysis with Deep Neural Networks},
booktitle={Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - Volume 4: BIOSIGNALS},
year={2018},
pages={36-47},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006596400360047},
isbn={978-989-758-279-0},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - Volume 4: BIOSIGNALS
TI - Real-time Low SNR Signal Processing for Nanoparticle Analysis with Deep Neural Networks
SN - 978-989-758-279-0
AU - Lenssen J.
AU - Toma A.
AU - Seebold A.
AU - Shpacovitch V.
AU - Libuschewski P.
AU - Weichert F.
AU - Chen J.
AU - Hergenröder R.
PY - 2018
SP - 36
EP - 47
DO - 10.5220/0006596400360047
PB - SciTePress