Early Prediction of MRSA Infections using Electronic Health Records

Thomas Hartvigsen, Cansu Sen, Sarah Brownell, Erin Teeple, Xiangnan Kong, Elke Rundensteiner

2018

Abstract

Despite eradication efforts, Methicillin-resistant Staphylococcus aureus (MRSA) remains a common cause of serious hospital-acquired infections (HAI) in the United States. Electronic Health Record (EHR) systems capture MRSA infection events along with detailed patient information preceding diagnosis. In this work, we design and apply machine learning methods to support early recognition of MRSA infection by estimating risk at several time points during hospitalization. We use EHR data including on-admission and throughout-stay patient information. On-admission features capture clinical and non-clinical information while throughout-stay features include vital signs, medications, laboratory studies, and other clinical assessments. We evaluate prediction accuracy achieved by core Machine Learning methods, namely Logistic Regression, Support Vector Machine, and Random Forest classifiers, when mining these different types of EHR features to detect patterns predictive of MRSA infection. We evaluate classification performance using MIMIC III – a critical care data set comprised of 12 years of patient records from the Beth Israel Deaconess Medical Center Intensive Care Unit in Boston, MA. Our methods can achieve near-perfect MRSA prediction accuracies one day before documented clinical diagnosis. Also, they perform well for early MRSA prediction many days in advance of diagnosis. These findings underscore the potential clinical applicability of machine learning techniques.

Paper Citation

in Harvard Style

Hartvigsen T., Sen C., Brownell S., Teeple E., Kong X. and Rundensteiner E. (2018). Early Prediction of MRSA Infections using Electronic Health Records. In Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - Volume 5: HEALTHINF; ISBN 978-989-758-281-3, SciTePress, pages 156-167. DOI: 10.5220/0006599601560167

in Bibtex Style

@conference{healthinf18,
author={Thomas Hartvigsen and Cansu Sen and Sarah Brownell and Erin Teeple and Xiangnan Kong and Elke Rundensteiner},
title={Early Prediction of MRSA Infections using Electronic Health Records},
booktitle={Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - Volume 5: HEALTHINF},
year={2018},
pages={156-167},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006599601560167},
isbn={978-989-758-281-3},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - Volume 5: HEALTHINF
TI - Early Prediction of MRSA Infections using Electronic Health Records
SN - 978-989-758-281-3
AU - Hartvigsen T.
AU - Sen C.
AU - Brownell S.
AU - Teeple E.
AU - Kong X.
AU - Rundensteiner E.
PY - 2018
SP - 156
EP - 167
DO - 10.5220/0006599601560167
PB - SciTePress