Association of Body Mass Index with Estimated Glomerular Filtration Rate and Incident Proteinuria

Seung Min Lee, Minseon Park, Hyung-Jin Yoon

2018

Abstract

Obesity has been one of the most important risk factors of chronic kidney disease (CKD). But the association of body mass index (BMI) with estimated glomerular filtration rate (eGFR) and incident proteinuria has not been studied well. The goal of this study was to elucidate the association of BMI with eGFR and proteinuria using nationwide health examination data. These associations were investigated with data of Korean adults who had undergone health screenings at least three times between 2009 and 2014. eGFR was calculated with Chronic Kidney Disease Epidemiology collaboration equation based on serum creatinine level. The association between BMI and eGFR was analysed with a generalized addictive model adjusting for possible confounders. Similarly, the association between BMI and incident proteinuria was analysed with Cox hazard model adjusting for possible confounders. As a result, a V-shape relationship between BMI and eGFR was observed. The nadir was around 29 kg/m2. With subgroup analyses for the association between BMI and eGFR, a V-shape association was observed in men and younger age group and an inverse association was observed in women and older age group. A reverse J-shape association between BMI and the adjusted hazard ratio of incident proteinuria was observed. The nadir was approximately estimated around 22 kg/m2.

Paper Citation

in Harvard Style

Lee S., Park M. and Yoon H. (2018). Association of Body Mass Index with Estimated Glomerular Filtration Rate and Incident Proteinuria. In Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - Volume 5: HEALTHINF; ISBN 978-989-758-281-3, SciTePress, pages 587-590. DOI: 10.5220/0006716905870590

in Bibtex Style

@conference{healthinf18,
author={Seung Min Lee and Minseon Park and Hyung-Jin Yoon},
title={Association of Body Mass Index with Estimated Glomerular Filtration Rate and Incident Proteinuria},
booktitle={Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - Volume 5: HEALTHINF},
year={2018},
pages={587-590},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006716905870590},
isbn={978-989-758-281-3},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - Volume 5: HEALTHINF
TI - Association of Body Mass Index with Estimated Glomerular Filtration Rate and Incident Proteinuria
SN - 978-989-758-281-3
AU - Lee S.
AU - Park M.
AU - Yoon H.
PY - 2018
SP - 587
EP - 590
DO - 10.5220/0006716905870590
PB - SciTePress