An in Silico Approach for Understanding the Complex Intercellular Interaction Patterns in Cancer Cells

Maura Cárdenas-García, Pedro Pablo González Pérez

2018

Abstract

Intercellular interaction allows cancer cells to preserve their malignance and through cell junctions to induce malignance in neighbouring cells and receive nutrients from them. The Wnt (wingless-related integration site) signalling pathway plays an important role in the formation of intercellular communications. In this work, we explore the complex interactions patterns of intercellular communication in cancer cells using an in silico modelling and simulation methodology developed by us. The proposed cellular signalling model, characterized by a multicompartmental nature, provides symbolic abstractions and accurate algorithms to model both intracellular and intercellular behaviours. In particular, in this work, we propose an in silico model and simulation of the formation of different communication channels, involving the Wnt signalling pathway. The final purpose of this study is to propose target molecules leading to break the communication between a cancer cell and surrounding normal cells. In this way, it is not necessary to carry out long series of different in vitro experiments, but only a few, because the focus should be only on the key molecules, which saves time and money. We observed, using in silico experiments, how the inhibition of Wnt signalling pathway prevents that the cells surrounding a cancerous cell are transformed.

Paper Citation

in Harvard Style

Cárdenas-García M. and González Pérez P. (2018). An in Silico Approach for Understanding the Complex Intercellular Interaction Patterns in Cancer Cells. In Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - Volume 3: BIOINFORMATICS; ISBN 978-989-758-280-6, SciTePress, pages 188-195. DOI: 10.5220/0006722601880195

in Bibtex Style

@conference{bioinformatics18,
author={Maura Cárdenas-García and Pedro Pablo González Pérez},
title={An in Silico Approach for Understanding the Complex Intercellular Interaction Patterns in Cancer Cells},
booktitle={Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - Volume 3: BIOINFORMATICS},
year={2018},
pages={188-195},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006722601880195},
isbn={978-989-758-280-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - Volume 3: BIOINFORMATICS
TI - An in Silico Approach for Understanding the Complex Intercellular Interaction Patterns in Cancer Cells
SN - 978-989-758-280-6
AU - Cárdenas-García M.
AU - González Pérez P.
PY - 2018
SP - 188
EP - 195
DO - 10.5220/0006722601880195
PB - SciTePress