The Effect of Pakoasi (Chromolaena odorata L.) Leaf Extract in Curing Open Wound of Rabbit Skin (Oryctolagus cuniculus)

F Ramdani, M Sriasih, A.S. Drajat

2018

Abstract

Pakoasi (Chromolaena odorata. L) is a weed that is often used in treating wounds, but its effectiveness has not been widely studied. The purpose of this research was to evaluate the effect of Pakoasi leaf extract on open wound healing process in rabbit. Twenty healthy male rabbits were wounded with diameter of 2 cm under local anaesthesia, and were divided into four groups: G0 (placebo), G1 (treated with 10% extract), G2 (treated with 20% extract) and G3 (positive control). Macroscopic and microscopic observations were carried out, and the obtained data were analysed using analysis of variance. The macroscopic results showed that on day 4, there was a significant difference (p <0.05) of wound diameter among groups, with G1 showing the shortest wound diameter (1.78 ± 0.08cm). Seventeen days after treatment, the wound diameter (cm) in G1, G2, G3 and G0 were 0 ± 0; 0.08 ± 0.04; 0.17 ± 0.06 and 0.35 ± 0.08, respectively. The complete healing process of open wound occurred as fast as 16 days after treatment in G1 based on macroscopic and microscopic observation. This study concluded that ointment containing 10% of pakoasi extract is effective for curing open wound.

Paper Citation

in Harvard Style

Ramdani F., Sriasih M. and Drajat A. (2018). The Effect of Pakoasi (Chromolaena odorata L.) Leaf Extract in Curing Open Wound of Rabbit Skin (Oryctolagus cuniculus).In Proceedings of the 2nd International Conference Postgraduate School - Volume 1: ICPS, ISBN 978-989-758-348-3, pages 457-461. DOI: 10.5220/0007544904570461

in Bibtex Style

@conference{icps18,
author={F Ramdani and M Sriasih and A.S. Drajat},
title={The Effect of Pakoasi (Chromolaena odorata L.) Leaf Extract in Curing Open Wound of Rabbit Skin (Oryctolagus cuniculus)},
booktitle={Proceedings of the 2nd International Conference Postgraduate School - Volume 1: ICPS,},
year={2018},
pages={457-461},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007544904570461},
isbn={978-989-758-348-3},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd International Conference Postgraduate School - Volume 1: ICPS,
TI - The Effect of Pakoasi (Chromolaena odorata L.) Leaf Extract in Curing Open Wound of Rabbit Skin (Oryctolagus cuniculus)
SN - 978-989-758-348-3
AU - Ramdani F.
AU - Sriasih M.
AU - Drajat A.
PY - 2018
SP - 457
EP - 461
DO - 10.5220/0007544904570461