Comparation of Estradiol and Estriol Serum Levels in Different Degrees of Melasma Severity in Pregnant Women

Tantari Sugiman, Dyah Ayu Savitri, Arif Widiatmoko

2018

Abstract

Estrogen, estradiol and estriol, is known to be capable of inducing melanogenesis and have been held responsible for the pigmentation seen in pregnancy. This study was conducted to analyse serum levels of estradiol and estriol in different degree of melasma severity in pregnant women. A cross-sectional study using continuous sampling in pregnant women with melasma conducted in June - July 2017 at Dr Saiful Anwar Regional General Hospital Malang, Indonesia. Inclusion criteria include pregnant women with melasma (15-49 years). Pregnant women with previous history of non-pregnancy melasma, who are taking hormonal contraceptives or taking hormonal drugs containing estrogen and taking phototoxic drugs excluded from the study. History, physical examination, Wood Lamp, and measurement severity melasma using MSS (Melasma Severity Score) was performed. Blood samples were drawn for serum estradiol and estriol serum examination using ELISA method. Result from 25 pregnant women with melasma divided into four groups, clear (6 subjects), mild (5 subjects), moderate (9 subjects) and severe (5 subjects). Estradiol serum levels mean were 417.80 (clear), 836.60 (mild), 793.58 (moderate) and 891.00 (severe). Estriol serum levels mean obtained on clear (94.67), mild (149.88), moderate (199.64) and severe (141.17). Significant different serum levels of estradiol found in each group of MSS (p=0.015) and serum levels estriol did not significantly differ in each group of MSS (p=0.454). This study concluded that estradiol serum levels in pregnant women with melasma were different in melasma severity degrees, but estriol serum levels were not different in melasma severity degrees.

Paper Citation

in Harvard Style

Sugiman T., Savitri D. and Widiatmoko A. (2018). Comparation of Estradiol and Estriol Serum Levels in Different Degrees of Melasma Severity in Pregnant Women.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 95-99. DOI: 10.5220/0008151600950099

in Bibtex Style

@conference{rcd18,
author={Tantari Sugiman and Dyah Ayu Savitri and Arif Widiatmoko},
title={Comparation of Estradiol and Estriol Serum Levels in Different Degrees of Melasma Severity in Pregnant Women},
booktitle={Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,},
year={2018},
pages={95-99},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008151600950099},
isbn={978-989-758-494-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD,
TI - Comparation of Estradiol and Estriol Serum Levels in Different Degrees of Melasma Severity in Pregnant Women
SN - 978-989-758-494-7
AU - Sugiman T.
AU - Savitri D.
AU - Widiatmoko A.
PY - 2018
SP - 95
EP - 99
DO - 10.5220/0008151600950099