Antihyperglycemic Activity of Ethanolic Herb Extract of Ceplukan (Physalis angulata L.) in Diabetic Hypercholesterolemia in Male Hamsters

Elly Wardani, Dwitiyanti, Sediarso, Dwina Puspandiyah

2018

Abstract

Diabetes mellitus is a disease characterized by hyperglycemia as well as progressive changes to the pancreatic beta cell structure. This study was conducted to determine the antihyperglycemic activity of ceplukan herb extract (Physalis angulata L.) in alloxan-induced male Syrian hamsters and high cholesterol feed. The study used 24 hamsters divided into six groups. Group I were given a standard diet and regular drinking water, Group II were given metformin dose 61,66 mg/kg body weight (BW), Group III were alloxan-induced and high cholesterol feed, Groups IV, V and VI were given extract dose 60, 120 and 240 mg/kg BW respectively. The animals were induced alloxan monohydrate as well as were given high cholesterol feed during treatment. Blood sampling was performed on the 29th and 44th day using a clinical spectrophotometer. The results show significant differences between treatment groups (α <0,05), followed by Tukey test. In conclusion, the preparation of herbal extract test ceplukan at doses of 120 and 240 mg/kg BW could reduce blood glucose levels by 50.84% and 43.41% which is equivalent to metformin dose of 61.66 mg/kg BW with a percentage of 53.12%.

Paper Citation

in Harvard Style

Wardani E., Dwitiyanti., Sediarso. and Puspandiyah D. (2018). Antihyperglycemic Activity of Ethanolic Herb Extract of Ceplukan (Physalis angulata L.) in Diabetic Hypercholesterolemia in Male Hamsters.In Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD, ISBN 978-989-758-349-0, pages 133-137. DOI: 10.5220/0008240601330137

in Harvard Style

Wardani E., Dwitiyanti., Sediarso. and Puspandiyah D. (2018). Antihyperglycemic Activity of Ethanolic Herb Extract of Ceplukan (Physalis angulata L.) in Diabetic Hypercholesterolemia in Male Hamsters.In Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD, ISBN 978-989-758-349-0, pages 133-137. DOI: 10.5220/0008240601330137

in Bibtex Style

@conference{mich-phd18,
author={Elly Wardani and Dwitiyanti and Sediarso and Dwina Puspandiyah},
title={Antihyperglycemic Activity of Ethanolic Herb Extract of Ceplukan (Physalis angulata L.) in Diabetic Hypercholesterolemia in Male Hamsters},
booktitle={Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD,},
year={2018},
pages={133-137},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008240601330137},
isbn={978-989-758-349-0},
}

in Bibtex Style

@conference{mich-phd18,
author={Elly Wardani and Dwitiyanti and Sediarso and Dwina Puspandiyah},
title={Antihyperglycemic Activity of Ethanolic Herb Extract of Ceplukan (Physalis angulata L.) in Diabetic Hypercholesterolemia in Male Hamsters},
booktitle={Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD,},
year={2018},
pages={133-137},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008240601330137},
isbn={978-989-758-349-0},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD,
TI - Antihyperglycemic Activity of Ethanolic Herb Extract of Ceplukan (Physalis angulata L.) in Diabetic Hypercholesterolemia in Male Hamsters
SN - 978-989-758-349-0
AU - Wardani E.
AU - Dwitiyanti.
AU - Sediarso.
AU - Puspandiyah D.
PY - 2018
SP - 133
EP - 137
DO - 10.5220/0008240601330137

in EndNote Style

TY - CONF

JO - Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD,
TI - Antihyperglycemic Activity of Ethanolic Herb Extract of Ceplukan (Physalis angulata L.) in Diabetic Hypercholesterolemia in Male Hamsters
SN - 978-989-758-349-0
AU - Wardani E.
AU - Dwitiyanti.
AU - Sediarso.
AU - Puspandiyah D.
PY - 2018
SP - 133
EP - 137
DO - 10.5220/0008240601330137