Polymorphism of Vitamin D Fok1 Receptor Gene in Patients with Pulmonary Tuberculosis of Batak Ethnic

Debby Mirani Lubis

2018

Abstract

Tuberculosis (TB) is one of the infectious diseases that is still a health problem of the world, especially in developing countries. The polymorphism of the vitamin D receptor gene (VDR) by some studies may affect the workings of vitamin D. The polymorphism of this receptor gene causes a person to become more susceptible to M. tuberculosis infection. This study aimed to determine polymorphism of Vitamin D Fok1 Receptor Gene in Patients with Pulmonary Tuberculosis of Batak Ethnic. A total of 42 patients who met the inclusion and exclusion criteria were examined for vitamin D Fok1 receptor gene with PCR-RFLP and analyzed by electrophoresis and the level of vitamin D was examined by ELISA. The results showed that 26 patients had Ff genotype (61,9%), 14 patients have FF genotype (33,3%), and two patients had ff genotype (4,8%). The most common level of Vitamin D in FF genotype was optimal (64,3%), in Ff genotype was optimal (53,8%), and ff genotype had the same percentatage of optimal and insufficiency level. Conclusion: Based on this research, the most common polymorphism of vitamin D Fok1 receptor gene in Batak ethnic is Ff genotype.

Paper Citation

in Harvard Style

Lubis D. (2018). Polymorphism of Vitamin D Fok1 Receptor Gene in Patients with Pulmonary Tuberculosis of Batak Ethnic.In Proceedings of the 2nd Syiah Kuala International Conference on Medicine and Health Sciences - Volume 1: SKIC-MHS, ISBN 978-989-758-438-1, pages 49-52. DOI: 10.5220/0008790600490052

in Bibtex Style

@conference{skic-mhs18,
author={Debby Mirani Lubis},
title={Polymorphism of Vitamin D Fok1 Receptor Gene in Patients with Pulmonary Tuberculosis of Batak Ethnic},
booktitle={Proceedings of the 2nd Syiah Kuala International Conference on Medicine and Health Sciences - Volume 1: SKIC-MHS,},
year={2018},
pages={49-52},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008790600490052},
isbn={978-989-758-438-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd Syiah Kuala International Conference on Medicine and Health Sciences - Volume 1: SKIC-MHS,
TI - Polymorphism of Vitamin D Fok1 Receptor Gene in Patients with Pulmonary Tuberculosis of Batak Ethnic
SN - 978-989-758-438-1
AU - Lubis D.
PY - 2018
SP - 49
EP - 52
DO - 10.5220/0008790600490052