Comparison of the Effectiveness in Administration of Lactulose, Probiotics and a Combination of Lactulose and Probiotics against Hepatic Encephalopathy in Patients with Liver Cirrhosis

Wahyuni, Fauzi Yusuf, Azzaki Abubakar, Desi Maghfirah

2018

Abstract

Hepatic Encephalopathy (HE) is one of the most common complication of decompensated liver cirrhosis. In chronic liver disease there will be a disruption of ammonia metabolism resulting in an increase of 5-10 times ammonia levels which will disrupt the physiology of the brain and brain metabolism. Treatment with laktulosa and probiotics can provide benefits in improving hepatic encephalopathy. The research subjects were divided into three groups: group A consisted of 17 people receiving 30-60ml/day lactulose, group B received one capsule probiotic taken three times per day (each capsule containing 2 billion of Lactobacillus acidophilus Rosell-52, 2 billion of Lactobacillus rhamnosus Rosell-11 2, 211 mg of Maltodextrin, 8mg of Magnesium stearate and 1 mg of ascorbic acid) and group C received both lactulose and probiotics. In our study, we found that there was an improvement in the degree of Hepatic Encephalopathy from severe HE to mild HE in two people (40%) from group A and one person (50%) from group C with p> 0.05.

Paper Citation

in Harvard Style

Yusuf F., Wahyuni., Abubakar A. and Maghfirah D. (2018). Comparison of the Effectiveness in Administration of Lactulose, Probiotics and a Combination of Lactulose and Probiotics against Hepatic Encephalopathy in Patients with Liver Cirrhosis.In Proceedings of the 2nd Syiah Kuala International Conference on Medicine and Health Sciences - Volume 1: SKIC-MHS, ISBN 978-989-758-438-1, pages 68-71. DOI: 10.5220/0008791000680071

in Bibtex Style

@conference{skic-mhs18,
author={Fauzi Yusuf and Wahyuni and Azzaki Abubakar and Desi Maghfirah},
title={Comparison of the Effectiveness in Administration of Lactulose, Probiotics and a Combination of Lactulose and Probiotics against Hepatic Encephalopathy in Patients with Liver Cirrhosis},
booktitle={Proceedings of the 2nd Syiah Kuala International Conference on Medicine and Health Sciences - Volume 1: SKIC-MHS,},
year={2018},
pages={68-71},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008791000680071},
isbn={978-989-758-438-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd Syiah Kuala International Conference on Medicine and Health Sciences - Volume 1: SKIC-MHS,
TI - Comparison of the Effectiveness in Administration of Lactulose, Probiotics and a Combination of Lactulose and Probiotics against Hepatic Encephalopathy in Patients with Liver Cirrhosis
SN - 978-989-758-438-1
AU - Yusuf F.
AU - Wahyuni.
AU - Abubakar A.
AU - Maghfirah D.
PY - 2018
SP - 68
EP - 71
DO - 10.5220/0008791000680071