Analysis of Degeneration Hepatosit Cell on Female Mice(Mus musculus) Induced by Ruthab Dates (Phoenix dactylifera) Extract and Paracetamol

Risa Purnamasari, Nurul Nahdiyah, Eko Teguh Pribadi, Sri Hidayati, Nova Lusiana, Funsu Andriarna, Moch Irfan Hadi, Hanik Faizah, Mohammad Yusuf Alamudi

2018

Abstract

Paracetamol is a drug used as an analgesic antipyretic. One of the fruits used as a hepatoprotection agent is Dates (Phoenix dactylifera) ruthab. This study aims to determine the hepatoprotective activity of various doses of ruthab date fruit extract against liver degeneration of female mice induced by paracetamol. This study used a group pre-experiment with the control group and group with dosing dates of 1, 3, and 7. While the experimental group was the group with 41.4 grams of paracetamol and the group given paracetamol and ruthab dose dates 7. The results of this study showed that there were no significant differences in various doses of ruthab dates extract in the pre-experimental group, although there was a decrease in the mean degeneration score. While the results of the experimental group, namely the group with the administration of ruthab and paracetamol dates, showed significant differences, indicating that there was a hepatoprotective activity of rutab dates extract. The existence of these differences was thought to be due to the flavonoid content in ruthab dates extract which acts as a hydrophilic and lipophilic antioxidant.

Paper Citation

in Harvard Style

Purnamasari R., Nahdiyah N., Pribadi E., Hidayati S., Lusiana N., Andriarna F., Hadi M., Faizah H. and Alamudi M. (2018). Analysis of Degeneration Hepatosit Cell on Female Mice(Mus musculus) Induced by Ruthab Dates (Phoenix dactylifera) Extract and Paracetamol. In Proceedings of the Built Environment, Science and Technology International Conference - Volume 1: BEST ICON, ISBN 978-989-758-414-5, pages 99-102. DOI: 10.5220/0008906600002481

in Bibtex Style

@conference{best icon18,
author={Risa Purnamasari and Nurul Nahdiyah and Eko Teguh Pribadi and Sri Hidayati and Nova Lusiana and Funsu Andriarna and Moch Irfan Hadi and Hanik Faizah and Mohammad Yusuf Alamudi},
title={Analysis of Degeneration Hepatosit Cell on Female Mice(Mus musculus) Induced by Ruthab Dates (Phoenix dactylifera) Extract and Paracetamol},
booktitle={Proceedings of the Built Environment, Science and Technology International Conference - Volume 1: BEST ICON,},
year={2018},
pages={99-102},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008906600002481},
isbn={978-989-758-414-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the Built Environment, Science and Technology International Conference - Volume 1: BEST ICON,
TI - Analysis of Degeneration Hepatosit Cell on Female Mice(Mus musculus) Induced by Ruthab Dates (Phoenix dactylifera) Extract and Paracetamol
SN - 978-989-758-414-5
AU - Purnamasari R.
AU - Nahdiyah N.
AU - Pribadi E.
AU - Hidayati S.
AU - Lusiana N.
AU - Andriarna F.
AU - Hadi M.
AU - Faizah H.
AU - Alamudi M.
PY - 2018
SP - 99
EP - 102
DO - 10.5220/0008906600002481