Brain Derived Neurotrophin Factor (BDNF) Level in Aged Sprague Dawley Rats Brain after the Treatment of Centella asiatica Leaf Extracts

Indah Fitriani, Nathaniel Aditya, Adisti Dwijayanti, Adisti Dwijayanti, Desak Gede Budi Krisnamurti, Desak Gede Budi Krisnamurti, Erni Hernawati Purwaningsih, Erni Hernawati Purwaningsih, Rani Wardani Hakim, Rani Wardani Hakim

2018

Abstract

Background: Functional decrease in learning and memory is one of the characteristics of the aging process. It has been known that a lower concentration of Brain Derived Neurotrophin Factor (BDNF) found on the brain, plays a role in the phenomenon. Objective: This study was designed to determine whether a herbal plant, Centella asiatica (CA), would increase the BDNF level on the aging brain tissue. Methods: 27 Male Sprague-Dawley rats aged 20-24 months and 4 weeks which were used in the study were divided into: negative control (were given aquadest), positive control (supplementation of Vitamin E), young rats as a comparison (4 weeks old), and treatment groups, which were given ethanol extract of CA leaves administered orally (300 mg/kg BW/week) for 28 days. At the end of the treatment, the rats were terminated and the brain BDNF levels were assessed. The data were analyzed by using a one-way ANOVA. Results: The results showed a mean concentration of BDNF for negative control, positive control group, young and treatment groups were 44.09±3.854, 43.09±11.99, 65.88±13.46, and 30.2±12.33 mmol/ml, respectively (p<0.05 vs control group). The treatment group showed a higher BDNF level compared to all the groups. Interestingly, the BDNF level showed in the positive control group were found to be lower than the treatment group. Conclusion: This result showed that the supplementation of CA was effective in increasing BDNF brain level, thus raising the potential of having a neuroprotective effect. These results implied the need of further research to find out the mechanism of neuroprotective function exerted by CA.

Paper Citation

in Harvard Style

Fitriani I., Aditya N., Dwijayanti A., Budi Krisnamurti D., Purwaningsih E. and Hakim R. (2018). Brain Derived Neurotrophin Factor (BDNF) Level in Aged Sprague Dawley Rats Brain after the Treatment of Centella asiatica Leaf Extracts. In Proceedings of BROMO Conference - Volume 1: BROMO, ISBN 978-989-758-347-6, pages 1-1. DOI: 10.5220/0009842400002406

in Bibtex Style

@conference{bromo18,
author={Indah Fitriani and Nathaniel Aditya and Adisti Dwijayanti and Desak Gede Budi Krisnamurti and Erni Hernawati Purwaningsih and Rani Wardani Hakim},
title={Brain Derived Neurotrophin Factor (BDNF) Level in Aged Sprague Dawley Rats Brain after the Treatment of Centella asiatica Leaf Extracts},
booktitle={Proceedings of BROMO Conference - Volume 1: BROMO,},
year={2018},
pages={1-1},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009842400002406},
isbn={978-989-758-347-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of BROMO Conference - Volume 1: BROMO,
TI - Brain Derived Neurotrophin Factor (BDNF) Level in Aged Sprague Dawley Rats Brain after the Treatment of Centella asiatica Leaf Extracts
SN - 978-989-758-347-6
AU - Fitriani I.
AU - Aditya N.
AU - Dwijayanti A.
AU - Budi Krisnamurti D.
AU - Purwaningsih E.
AU - Hakim R.
PY - 2018
SP - 1
EP - 1
DO - 10.5220/0009842400002406