Antihyperglycemic Effect and Glucose Tolerance of Ethanol Extract the Rind of Jengkol (Pithecollobium jiringa Jack) in Diabetic Rats

Muhammad Yanis Musdja, Weldy Marison, Ahmad Musir

2018

Abstract

In traditional medicine, the rind of jengkol or skin of jengkol fruit (Pithecellobium jiringa Jack) has been used by some people to reduce blood glucose levels in some districts of Indonesia. This study aims to determine the antihyperglycemic effect and glucose tolerance of ethanol extract of the rind of jengkol (Pithecollobium jiringa Jack) in diabetic rats. Jengkol fruit was bought from Kebonjeruk market, West Jakarta and determination of jengkol rind was done at the Biology Research Center, Indonesian Institute of Sciences, Bogor.Indonesia. Jengkol rind was separated from the fruit seeds. Preparation of jengkol rind extract was done by cold maceration extraction technique using ethanol 70%. The male albino rats that qualify for the experiment were made into diabetics using the alloxan method. The rats were divided into 7 groups, each group consisted of 5 rats. as positive control for anti-diabetic was used glibenclamide and for glucose tolerance test was used acarbose, as normal control just given aquadest and for negative control wass given a solution for suspending the test preparation (1% CMC Na). For extract of jengkol rind was given low dose ( 24,5 mg/200 gr bw), medium dose (49 mg/200 gr bw) and high dose (196 mg/200 gr bw) and glucometer tool was used to measure blood sugar levels. Statistical results with ANOVA test and Kruskal-wallis test showed that small and medium doses of jengkol rind extract had the same antidiabetic effect and glucose tolerance with positive control and were significantly different to negative controls. (P≤0.05). and high dose was not significantly different to negative controls (P≥0.05).

Paper Citation

in Harvard Style

Musdja M., Marison W. and Musir A. (2018). Antihyperglycemic Effect and Glucose Tolerance of Ethanol Extract the Rind of Jengkol (Pithecollobium jiringa Jack) in Diabetic Rats.In Proceedings of the 1st International Conference on Recent Innovations - Volume 1: ICRI, ISBN 978-989-758-458-9, pages 2245-2250. DOI: 10.5220/0009941322452250

in Bibtex Style

@conference{icri18,
author={Muhammad Yanis Musdja and Weldy Marison and Ahmad Musir},
title={Antihyperglycemic Effect and Glucose Tolerance of Ethanol Extract the Rind of Jengkol (Pithecollobium jiringa Jack) in Diabetic Rats},
booktitle={Proceedings of the 1st International Conference on Recent Innovations - Volume 1: ICRI,},
year={2018},
pages={2245-2250},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009941322452250},
isbn={978-989-758-458-9},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Recent Innovations - Volume 1: ICRI,
TI - Antihyperglycemic Effect and Glucose Tolerance of Ethanol Extract the Rind of Jengkol (Pithecollobium jiringa Jack) in Diabetic Rats
SN - 978-989-758-458-9
AU - Musdja M.
AU - Marison W.
AU - Musir A.
PY - 2018
SP - 2245
EP - 2250
DO - 10.5220/0009941322452250