Study of Dipeptidil Peptidase 4 Inhibitors based on Molecular Docking Experiments

A. A. Saraiva, A. A. Saraiva, J. N. Soares, Nator Junior C. Costa, José Vigno M. Sousa, José Vigno M. Sousa, N. M. Fonseca Ferreira, N. M. Fonseca Ferreira, Antonio Valente, Antonio Valente, Salviano Soares

2019

Abstract

The lack of physical activity and poor nutrition triggers various diseases, among them is diabetes. In this context, several researches seek ways that can mitigate these diseases to provide a better quality of life for people. Therefore, the present work aims to analyze the possible inhibitors of the enzyme Dipeptidil Peptidase 4 that hypotheses will be stipulated for the creation of new drugs through molecular docking techniques, that is, a computational simulation of combinations of drugs of the family of gliptins with other antidiabetics (metformin, glyburide and cucurbitacin). Among the results, it was observed that the antidiabetic cucurbitacin combined with the gliptines obtained greater energy during the process.

Paper Citation

in Harvard Style

Saraiva A., Soares J., Junior C. Costa N., Vigno M. Sousa J., Ferreira N., Valente A. and Soares S. (2019). Study of Dipeptidil Peptidase 4 Inhibitors based on Molecular Docking Experiments. In Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2019) - Volume 3: BIOINFORMATICS; ISBN 978-989-758-353-7, SciTePress, pages 322-330. DOI: 10.5220/0007692203220330

in Bibtex Style

@conference{bioinformatics19,
author={A. A. Saraiva and J. N. Soares and Nator Junior C. Junior C. Costa and José Vigno M. Vigno M. Sousa and N. M. Fonseca Ferreira and Antonio Valente and Salviano Soares},
title={Study of Dipeptidil Peptidase 4 Inhibitors based on Molecular Docking Experiments},
booktitle={Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2019) - Volume 3: BIOINFORMATICS},
year={2019},
pages={322-330},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007692203220330},
isbn={978-989-758-353-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2019) - Volume 3: BIOINFORMATICS
TI - Study of Dipeptidil Peptidase 4 Inhibitors based on Molecular Docking Experiments
SN - 978-989-758-353-7
AU - Saraiva A.
AU - Soares J.
AU - Junior C. Costa N.
AU - Vigno M. Sousa J.
AU - Ferreira N.
AU - Valente A.
AU - Soares S.
PY - 2019
SP - 322
EP - 330
DO - 10.5220/0007692203220330
PB - SciTePress