Endothelial Protective and Antioxidant Effect of Polysaccharide Peptide of Ganoderma Lucidum in STEMI and NSTEMI Patients with Diabetes as a Risk Factor

Djanggan Sargowo, Nurul Aini Rahmawati, Nurul Aini Rahmawati, Faris Wahyu Nugroho, Putri Annisa Kamila, Dedy Irawan, Monika Sitio, Liemena Harold Adrian, Aditya Reza Pratama, Yusuf Arifin, Rizki Fadlan, Diah Ivana Sari, Chamelia Rohadatul 'Aissy, Evita Febrianti Purwanto, Firyal Nadiah Rahmah, Merkuri Puspasari Sukatman, Rakhmawati Fahmiy

2019

Abstract

Diabetes induced increases of Reactive Oxygens Species (ROS) Production. Oxidative stress and endothelial dysfunction are induced by high free radical. In Previous studies has been found that PsP of Ganoderma Lucidum has no toxicity in animal model and can be act as an antioxidants and antiendothelial dysfunction. This study was purposed to prove the effect of PsP of Ganoderma Lucidum as antioxidant and protective endothelial cell in STEMI and NSTEMI patients with diabetes. This clinical trial study conducted to 50 patients that diagnosed STEMI, NSTEMI and Diabetes, with pre- and post-test control group design. The parameters are MDA, SOD, CEC, and EPC counts. Patients divided into two group randomized, one group were given PsP Ganoderma Lucidum 750mg/day in 3 divided dose, and another group were given placebo for 90days. Normally distributed data will be analyzed by Dependent T-test and abnormally distributed data will be analyze by Wilcoxon test. The result are in PsP group patiens MDA level significantly decreased with P=0,030, SOD significantly increased with P=0,000, EPC count significantly increased with P=0,016, CEC count significantly decreased with P= 0,020. It concluded PsP of Ganoderma Lucidum act as antioxidant and protective endothelial cell against pathogenesis of atherosclerosis in STEMI and NSTEMI patients with diabetes.

Paper Citation

in Harvard Style

Sargowo D., Rahmawati N., Rahmawati N., Nugroho F., Kamila P., Irawan D., Sitio M., Adrian L., Pratama A., Arifin Y., Fadlan R., Sari D., 'Aissy C., Purwanto E., Rahmah F., Sukatman M. and Fahmiy R. (2019). Endothelial Protective and Antioxidant Effect of Polysaccharide Peptide of Ganoderma Lucidum in STEMI and NSTEMI Patients with Diabetes as a Risk Factor.In Proceedings of the 2nd Health Science International Conference - Volume 1: HSIC, ISBN 978-989-758-462-6, pages 60-65. DOI: 10.5220/0009121700600065

in Bibtex Style

@conference{hsic19,
author={Djanggan Sargowo and Nurul Aini Rahmawati and Nurul Aini Rahmawati and Faris Wahyu Nugroho and Putri Annisa Kamila and Dedy Irawan and Monika Sitio and Liemena Harold Adrian and Aditya Reza Pratama and Yusuf Arifin and Rizki Fadlan and Diah Ivana Sari and Chamelia Rohadatul 'Aissy and Evita Febrianti Purwanto and Firyal Nadiah Rahmah and Merkuri Puspasari Sukatman and Rakhmawati Fahmiy},
title={Endothelial Protective and Antioxidant Effect of Polysaccharide Peptide of Ganoderma Lucidum in STEMI and NSTEMI Patients with Diabetes as a Risk Factor},
booktitle={Proceedings of the 2nd Health Science International Conference - Volume 1: HSIC,},
year={2019},
pages={60-65},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009121700600065},
isbn={978-989-758-462-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd Health Science International Conference - Volume 1: HSIC,
TI - Endothelial Protective and Antioxidant Effect of Polysaccharide Peptide of Ganoderma Lucidum in STEMI and NSTEMI Patients with Diabetes as a Risk Factor
SN - 978-989-758-462-6
AU - Sargowo D.
AU - Rahmawati N.
AU - Rahmawati N.
AU - Nugroho F.
AU - Kamila P.
AU - Irawan D.
AU - Sitio M.
AU - Adrian L.
AU - Pratama A.
AU - Arifin Y.
AU - Fadlan R.
AU - Sari D.
AU - 'Aissy C.
AU - Purwanto E.
AU - Rahmah F.
AU - Sukatman M.
AU - Fahmiy R.
PY - 2019
SP - 60
EP - 65
DO - 10.5220/0009121700600065