The Effect of Poguntano Leaf Extract (Curanga feel-terrae Merr.) on Procalcitonin Levels in Acute Bacterial Rhinosinusitis Rat Model

Andrina Yunita Murni Rambe, Delfitri Munir, Rosita Juwita Sembiring, Syafruddin Ilyas

2019

Abstract

Background: Acute rhinosinusitis is a common condition caused by a viral and bacterial infection. Procalcitonin (PCT) has been proofed as a biomarker for bacterial infections. PCT levels increase to higher levels in bacterial infection. The extract of Poguntano leaf contains phytochemicals namely flavonoids, saponins, tannins, glycosides, terpenoids, and steroids. Objective : This study aimed to determine the effect of Poguntano leaf extract on Procalcitonin level expression in acute bacterial rhinosinusitis rats model Methods : Twenty-four female Wistar rats were divided randomly into three groups, negative control (group A), positive control (group B), group obtaining Poguntano extract 10mg/kg/day orally for 5 days at the 10th day after induction (group C). Rhinosinusitis was induced by the insertion of sponge impregnated with a solution containing Staphylococcus aureus into nasal cavities of study group B and C. The groups were euthanized within 1 day (group A), 10 days (group B), and 15 days (group C). Procalcitonin blood level was measured by ELISA. Results: there was a significant reduction of Procalcitonin levels in the treatment group than in the control group. Conclusion: this study suggests that Poguntano leaf can reduce procalcitonin levels in a rat model of acute bacterial rhinosinusitis.

Paper Citation

in Harvard Style

Rambe A., Munir D., Sembiring R. and Ilyas S. (2019). The Effect of Poguntano Leaf Extract (Curanga feel-terrae Merr.) on Procalcitonin Levels in Acute Bacterial Rhinosinusitis Rat Model.In Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI, ISBN 978-989-758-469-5, pages 19-23. DOI: 10.5220/0009847800190023

in Bibtex Style

@conference{ictromi19,
author={Andrina Yunita Murni Rambe and Delfitri Munir and Rosita Juwita Sembiring and Syafruddin Ilyas},
title={The Effect of Poguntano Leaf Extract (Curanga feel-terrae Merr.) on Procalcitonin Levels in Acute Bacterial Rhinosinusitis Rat Model},
booktitle={Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,},
year={2019},
pages={19-23},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009847800190023},
isbn={978-989-758-469-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,
TI - The Effect of Poguntano Leaf Extract (Curanga feel-terrae Merr.) on Procalcitonin Levels in Acute Bacterial Rhinosinusitis Rat Model
SN - 978-989-758-469-5
AU - Rambe A.
AU - Munir D.
AU - Sembiring R.
AU - Ilyas S.
PY - 2019
SP - 19
EP - 23
DO - 10.5220/0009847800190023