Generalized Pustular Psoriasis in Childhood

Milka Wulansari Hartono, Ernawati Hidayat, Buwono Puruhito, Asih Budiastuti, Meira Dewi Kusuma Astuti

2019

Abstract

A Generalized pustular psoriasis is a rare form of psoriasis in children. The prevalence of psoriasis in children is ≈0.71%, the pustular type occurring in 0.6-7%.It is more severe in children and characterized by a generalized pustule, forming the lake of pus, on an erythematous base.A 9-year-old boy presented with fever and sudden onset of pustules eruption on erythematous base over the face, trunk, and extremities. There was no past or family history of psoriasis. The laboratory result was leucocyte count 14.000/ µL, CRP1,43 mg/L, qualitative ASTO (+). Histopathologic examination revealed skin lesions with psoriasiform reactions, microabscess munro (+), dermis contained adnexa of the skin, stroma hyperemia with lymphocytes, histiocytes, PMN leucocytes, supporting the diagnosis of generalized pustular psoriasis. Patient was treated with cyclosporine tablet 3 mg/kgbw/day, desoximetasone cream 0,25% twice daily,loratadine tablet 10 mg/day, paracetamol tablet3x500 mg.Generalized pustular psoriasis often requires systemic and topical therapy because of the severity of the disease.Cyclosporin is recommended as a first-line drug for pediatric generalized pustular psoriasis. Cyclosporin acts by inhibiting T-cell and IL-2. Treatment using oral cyclosporin gave a good outcome in this patient. The eruptions markedly improved after administration of oral cyclosporine 3 mg/kgbw/day for seven days.Topical treatment using a potent corticosteroid, which has anti‑inflammatory and antiproliferative properties were co-administered to increase the efficacy.Prognosis quo ad vitam ad bonam, quo ad sanam dubia ad bonam dan quo ad kosmetikamad bonam.

Paper Citation

in Harvard Style

Hartono M., Hidayat E., Puruhito B., Budiastuti A. and Astuti M. (2019). Generalized Pustular Psoriasis in Childhood.In Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI, ISBN 978-989-758-469-5, pages 352-356. DOI: 10.5220/0009988603520356

in Bibtex Style

@conference{ictromi19,
author={Milka Wulansari Hartono and Ernawati Hidayat and Buwono Puruhito and Asih Budiastuti and Meira Dewi Kusuma Astuti},
title={Generalized Pustular Psoriasis in Childhood},
booktitle={Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,},
year={2019},
pages={352-356},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009988603520356},
isbn={978-989-758-469-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,
TI - Generalized Pustular Psoriasis in Childhood
SN - 978-989-758-469-5
AU - Hartono M.
AU - Hidayat E.
AU - Puruhito B.
AU - Budiastuti A.
AU - Astuti M.
PY - 2019
SP - 352
EP - 356
DO - 10.5220/0009988603520356