Corticosteroid Pulse Therapy for the Treatment of Bullous Systemic Lupus Erythematosus with Lupus Nephritis

Hayra Diah Avianggi, Intan Nurmawati, Radityastuti, Widyawati, Meira Dewi Kusuma

2019

Abstract

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Skin involvement occurs in nearly 76 % of all lupus patients. The Bullous Systemic Lupus Erythematosus (BSLE) is a rare cutaneous variant of SLE, affecting in less than 1%. A26-year-old female with a history of a vesiculobullous eruption on face, neck, trunks, andarms, along with oral mucosa ulcers.She hadphotosensitivity, a non-scarring alopecia, hemolytic anemia, serositis, arthralgia, renal impairment, and high antibody titers confirmingSLE. Histopathologicalexamination showed features in accordance with SLE, tends to beBSLE. The renal biopsy confirmed the features of lupus nephritis. The patient was diagnosed as BSLE based on the Systemic Lupus International Collaborating Clinics (SLICC) criteria, location of a blister, and histopathologicfinding. She responded well to systemic corticosteroid pulse therapy. BSLE should be considered as a differential diagnosis among patients with bullous lesions.It is vital to prevent the complication of SLE, that is lupus nephritis because it relates to a worse prognosis. We choose corticosteroid given as pulsed therapy to enhance the therapeutic effect and reduce the side effects, followed by azathioprine as sparing agent. Systemic corticosteroid pulse therapy is considered as first-line therapy, with azathioprine which has been proved to be effective in maintaining disease remission. The objectiveof BSLE therapy is to prevent new blisters, promote healing, and prevent scarring.Prognosis ad vitamdubiaadbonam, ad sanamdubiaadmalam, ad cosmetic dubiaadbonam.

Paper Citation

in Harvard Style

Avianggi H., Nurmawati I., Radityastuti., Widyawati. and Kusuma M. (2019). Corticosteroid Pulse Therapy for the Treatment of Bullous Systemic Lupus Erythematosus with Lupus Nephritis.In Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI, ISBN 978-989-758-469-5, pages 357-361. DOI: 10.5220/0009988803570361

in Bibtex Style

@conference{ictromi19,
author={Hayra Diah Avianggi and Intan Nurmawati and Radityastuti and Widyawati and Meira Dewi Kusuma},
title={Corticosteroid Pulse Therapy for the Treatment of Bullous Systemic Lupus Erythematosus with Lupus Nephritis},
booktitle={Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,},
year={2019},
pages={357-361},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009988803570361},
isbn={978-989-758-469-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,
TI - Corticosteroid Pulse Therapy for the Treatment of Bullous Systemic Lupus Erythematosus with Lupus Nephritis
SN - 978-989-758-469-5
AU - Avianggi H.
AU - Nurmawati I.
AU - Radityastuti.
AU - Widyawati.
AU - Kusuma M.
PY - 2019
SP - 357
EP - 361
DO - 10.5220/0009988803570361