Efficacy of Topical Β Blockers (0,25% Timolol Maleate Eye Drops®) in Treatment of Infantile Hemangioma

Wizar Putri Mellaratna, Deryne Anggia Paramita

2019

Abstract

Introduction: Infantile hemangioma (IH) is a benign vascular tumor, that occurs several weeks after birth. Pathogenesis of IH considers an escalation of angiogenesis, vasculogenesis in proliferative phases and apoptosis in regression phases. Since 2010, topical timolol maleate has used as a treatment of superficial and non-ulcerated IH. Case: A 2 months 25 days infant admitted to our hospital with a history of bright red swelling on his left forehead. The lesion appeared first like a mosquito bite swelling when the patient was three weeks old, then lesion enlarged and the color became more erythematous.Dermatology examination indicated solitaryerythematous nodule, size 0,7x0,3x0,05 cm3, stepping border, and cobblestone surface, rubbery consistency, and warm on left temporal. The hemangioma severity scale (HSS) was six, and hemangioma dynamic complication scale (HDCS) was 0. The patient was treated with topical β blocker timolol maleate eye drop 0,25%®, one drop twice a day.Three months after treatment, the regression of the lesion was significantwith size 0,5x0,1x0,01 cm3. Discussion: Topical β blocker indicated in our caseto reduce the risk of functional compromise such as ulceration, scar, and risk for residual skin development include telangiectasia, redundant skin, and fibrofatty tissue after involution phases. Timolol maleate 0,25% 1 drops two times a day resulted in regression of superficial IH, topical and lower concentration used reduces the risk of side effects. Conclusions: Importance to determine the effective treatment for IH based on some points include anatomic depth, morphology, and risk for complication, functional compromise, and permanent disfigurement.

Paper Citation

in Harvard Style

Mellaratna W. and Paramita D. (2019). Efficacy of Topical Β Blockers (0,25% Timolol Maleate Eye Drops®) in Treatment of Infantile Hemangioma.In Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI, ISBN 978-989-758-469-5, pages 455-459. DOI: 10.5220/0009991404550459

in Bibtex Style

@conference{ictromi19,
author={Wizar Putri Mellaratna and Deryne Anggia Paramita},
title={Efficacy of Topical Β Blockers (0,25% Timolol Maleate Eye Drops®) in Treatment of Infantile Hemangioma},
booktitle={Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,},
year={2019},
pages={455-459},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009991404550459},
isbn={978-989-758-469-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,
TI - Efficacy of Topical Β Blockers (0,25% Timolol Maleate Eye Drops®) in Treatment of Infantile Hemangioma
SN - 978-989-758-469-5
AU - Mellaratna W.
AU - Paramita D.
PY - 2019
SP - 455
EP - 459
DO - 10.5220/0009991404550459