The Role of Chlorogenic Acid on Mice with Unilateral Ureteral Obstruction Model: A Study toward Tubular Injury

Gina Andyka Hutasoit, Nur Arfian, Dwi Cahyani Ratna Sari, Gabriella Bamba Ratih Lintin, Mohammad Salman, Muhammad Mansyur Romi

2020

Abstract

Chronic kidney disease is a global public health problem with a poor prognosis of renal fibrosis. Injury to tubular epithelial cells is the beginning of the occurrence of renal fibrosis. Unilateral Ureteral Obstruction (UUO) is a representative method for obtaining models of renal fibrosis. Chlorogenic acid (CGA) is known to have a renoprotective, anti-inflammatory and antioxidant effect. This study aims to examine the role of CGA preventing tubular injury on mice with UUO model. This study was a quasi-experimental research with post-test only with control group design. Subjects were 25 male adult Swiss Webster mice (2-3 months old, 20-30 g weight). Subjects were divided into five groups: SO (Sham Operation), U7 (UUO day-7), U14 (UUO day-14), UC7 (UUO+CGA day-7) and UC14 (UUO+CGA day-14). CGA 14 mg/kg body weight/day was induced intraperitoneally. Tubular injury scores were examined with Periodic Acid Schiff staining. The data obtained from this study were analyzed using SPSS. UUO group with CGA showed the tubular injury score was lower than the UUO group without CGA with p-value < 0,005. The application of chlorogenic acid could prevent tubular injury in mice model of UUO

Paper Citation

in Harvard Style

Hutasoit G., Arfian N., Ratna Sari D., Ratih Lintin G., Salman M. and Romi M. (2020). The Role of Chlorogenic Acid on Mice with Unilateral Ureteral Obstruction Model: A Study toward Tubular Injury.In Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC, ISBN 978-989-758-499-2, pages 58-62. DOI: 10.5220/0010487700580062

in Bibtex Style

@conference{jimc20,
author={Gina Andyka Hutasoit and Nur Arfian and Dwi Cahyani Ratna Sari and Gabriella Bamba Ratih Lintin and Mohammad Salman and Muhammad Mansyur Romi},
title={The Role of Chlorogenic Acid on Mice with Unilateral Ureteral Obstruction Model: A Study toward Tubular Injury},
booktitle={Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,},
year={2020},
pages={58-62},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010487700580062},
isbn={978-989-758-499-2},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,
TI - The Role of Chlorogenic Acid on Mice with Unilateral Ureteral Obstruction Model: A Study toward Tubular Injury
SN - 978-989-758-499-2
AU - Hutasoit G.
AU - Arfian N.
AU - Ratna Sari D.
AU - Ratih Lintin G.
AU - Salman M.
AU - Romi M.
PY - 2020
SP - 58
EP - 62
DO - 10.5220/0010487700580062