Development of HIV-1 Coreceptor Tropism Classifiers: An Approach to Improve X4 and R5X4 Viruses Prediction

José Fernando dos Anjos Rodrigues, Letícia Martins Raposo, Letícia Martins Raposo, Flavio Fonseca Nobre

2020

Abstract

The pathway of human immunodeficiency virus (HIV) infection depends on the composition of a 35-amino acid variable region in its envelope, known as the V3 loop. Since this discovery, many tools have been developed to diagnose and predict viral tropism, from biochemical tests to various computational algorithms. To date, the biggest developmental difficulty is the correct prediction of X4 or R5X4-tropism virions. In this study, we evaluated some of these recommended criteria and proposed a random forest-based approach for better prediction of X4-capable (i.e., either X4-only, or R5X4-dual/mixed capability). All methods achieved a specificity higher than 87%, with geno2pheno 2.5% showing the best performance (98.2%). Nevertheless, the sensitivity (73.3%) was lower compared to the other approaches. The highest sensitivity was attained by our Complete Model with an undersampling strategy (90.1%). The accuracy of all approaches ranged from 87.4% to 93.0%. Complete Model with oversampling and Reduced Model with no balancing showed the highest MCC value (both with 0.796 score). Considering error rates and the number of explanatory variables, our main objective of increasing the ability to predict viral specimens with X4-tropism was achieved.

Paper Citation

in Harvard Style

Rodrigues J., Raposo L. and Nobre F. (2020). Development of HIV-1 Coreceptor Tropism Classifiers: An Approach to Improve X4 and R5X4 Viruses Prediction. In Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2020) - Volume 3: BIOINFORMATICS; ISBN 978-989-758-398-8, SciTePress, pages 183-187. DOI: 10.5220/0009096101830187

in Bibtex Style

@conference{bioinformatics20,
author={José Fernando dos Anjos Rodrigues and Letícia Martins Raposo and Flavio Fonseca Nobre},
title={Development of HIV-1 Coreceptor Tropism Classifiers: An Approach to Improve X4 and R5X4 Viruses Prediction},
booktitle={Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2020) - Volume 3: BIOINFORMATICS},
year={2020},
pages={183-187},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009096101830187},
isbn={978-989-758-398-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2020) - Volume 3: BIOINFORMATICS
TI - Development of HIV-1 Coreceptor Tropism Classifiers: An Approach to Improve X4 and R5X4 Viruses Prediction
SN - 978-989-758-398-8
AU - Rodrigues J.
AU - Raposo L.
AU - Nobre F.
PY - 2020
SP - 183
EP - 187
DO - 10.5220/0009096101830187
PB - SciTePress