Preliminary Evaluation of the Utility of Deep Generative Histopathology Image Translation at a Mid-sized NCI Cancer Center

Joshua J. Levy, Joshua J. Levy, Joshua J. Levy, Christopher R. Jackson, Aravindhan Sriharan, Brock C. Christensen, Louis J. Vaickus

2020

Abstract

Evaluation of a tissue biopsy is often required for the diagnosis and prognostic staging of a disease. Recent efforts have sought to accurately quantitate the distribution of tissue features and morphology in digitized images of histological tissue sections, Whole Slide Images (WSI). Generative modeling techniques present a unique opportunity to produce training data that can both augment these models and translate histologic data across different intra-and-inter-institutional processing procedures, provide cost-effective ways to perform computational chemical stains (synthetic stains) on tissue, and facilitate the creation of diagnostic aid algorithms. A critical evaluation and understanding of these technologies is vital for their incorporation into a clinical workflow. We illustrate several potential use cases of these techniques for the calculation of nuclear to cytoplasm ratio, synthetic SOX10 immunohistochemistry (IHC, sIHC) staining to delineate cell lineage, and the conversion of hematoxylin and eosin (H&E) stain to trichome stain for the staging of liver fibrosis.

Paper Citation

in Harvard Style

Levy J., Jackson C., Sriharan A., Christensen B. and Vaickus L. (2020). Preliminary Evaluation of the Utility of Deep Generative Histopathology Image Translation at a Mid-sized NCI Cancer Center. In Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: C2C, ISBN 978-989-758-398-8, pages 302-311. DOI: 10.5220/0009427603020311

in Bibtex Style

@conference{c2c20,
author={Joshua Levy and Christopher Jackson and Aravindhan Sriharan and Brock Christensen and Louis Vaickus},
title={Preliminary Evaluation of the Utility of Deep Generative Histopathology Image Translation at a Mid-sized NCI Cancer Center},
booktitle={Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: C2C,},
year={2020},
pages={302-311},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009427603020311},
isbn={978-989-758-398-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: C2C,
TI - Preliminary Evaluation of the Utility of Deep Generative Histopathology Image Translation at a Mid-sized NCI Cancer Center
SN - 978-989-758-398-8
AU - Levy J.
AU - Jackson C.
AU - Sriharan A.
AU - Christensen B.
AU - Vaickus L.
PY - 2020
SP - 302
EP - 311
DO - 10.5220/0009427603020311