Front-end Design Optimization for Ionoacoustic 200 MeV Protons Beam Monitoring with Sub-millimeter Precision for Hadron Therapy Applications

Elia Arturo Vallicelli, Elia Arturo Vallicelli, Mattia Oliver Cosmi, Andrea Baschirotto, Andrea Baschirotto, Marcello De Matteis, Marcello De Matteis

2021

Abstract

This paper presents the design of a multichannel acoustic detector optimized for sensing proton induced thermo-acoustic signals (ionoacoustic signals) in clinical scenarios experiments. Ionoacoustics is a promising technique for real-time monitoring of proton beams with interesting possible applications in oncological hadron therapy. However, clinical scenarios are characterized by very low signal amplitudes (few tens millipascals). State-of-the-art experiments use general purpose acoustic sensors and heavily rely on averaging (up to thousands beam shots) to detect a clear signal, at the cost of a significant extra-dose above clinical limits. To overcome this limit, this paper presents the design of a dedicated acoustic sensor that exploits spatial correlation (multichannel sensor) to increase the SNR with no extra-dose and localize the maximum energy deposition of a 200 MeV proton beam in clinical scenarios (35 mGy/shot dose, 25 mPa signal amplitude). The results are validated by a complete cross-domain simulation of the physical (proton beam), acoustic (wave propagation) and electrical (sensor and electronics frequency response and noise) environments. The presented detector achieves a clear 20.5 dB single-shot SNR (35 mGy total dose) and can localize the maximum energy deposition with 0.5 mm precision (<1% w.r.t. the particle range) with ~1/100 dose reduction compared to state-of-the-art.

Paper Citation

in Harvard Style

Vallicelli E., Cosmi M., Baschirotto A. and De Matteis M. (2021). Front-end Design Optimization for Ionoacoustic 200 MeV Protons Beam Monitoring with Sub-millimeter Precision for Hadron Therapy Applications. In Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2021) - Volume 1: BIODEVICES; ISBN 978-989-758-490-9, SciTePress, pages 77-87. DOI: 10.5220/0010346600002865

in Bibtex Style

@conference{biodevices21,
author={Elia Arturo Vallicelli and Mattia Oliver Cosmi and Andrea Baschirotto and Marcello De Matteis},
title={Front-end Design Optimization for Ionoacoustic 200 MeV Protons Beam Monitoring with Sub-millimeter Precision for Hadron Therapy Applications},
booktitle={Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2021) - Volume 1: BIODEVICES},
year={2021},
pages={77-87},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010346600002865},
isbn={978-989-758-490-9},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2021) - Volume 1: BIODEVICES
TI - Front-end Design Optimization for Ionoacoustic 200 MeV Protons Beam Monitoring with Sub-millimeter Precision for Hadron Therapy Applications
SN - 978-989-758-490-9
AU - Vallicelli E.
AU - Cosmi M.
AU - Baschirotto A.
AU - De Matteis M.
PY - 2021
SP - 77
EP - 87
DO - 10.5220/0010346600002865
PB - SciTePress