The Effect of Different Intensities of Treadmill Exercise on FGF23 Gene Expression in Gastrocnemius and Soleus Muscles of Wistar Rats

Julia Gunadi, Julia Gunadi, Diana Jasaputra, Diana Jasaputra, Decky Gunawan, Ludovicus Edwinanto, Limdawati Kwee, Harijadi Pramono, Adrian Suhendra, Ghita Sariwidyantry, Hanna Goenawan, Hanna Goenawan, Ronny Lesmana, Ronny Lesmana

2021

Abstract

Fibroblast growth factor 23 (FGF23) acts as a hormone that regulates phosphate metabolism associated with kidney function, and an inducer of left ventricle hypertrophy. But the role of FGF23 as a myokine has not yet to be confirmed. This research aims to investigate the effect of different intensities of treadmill exercise on FGF23 gene expression in gastrocnemius and soleus muscles of Wistar rats. Twenty male Wistar rats were given different intensities of treadmill exercise (low, moderate, and high) for as long as 8 weeks. FGF23 gene expression in gastrocnemius and soleus muscles was examined using semi-quantitative PCR. In this study, we obtained no change of relative FGF23 mRNA expression in gastrocnemius muscles (p = 0.684) compared to control. But interestingly, we found a significant increase of relative FGF23 mRNA expression in soleus muscles (p = 0.030). These results showed that different intensities of treadmill exercise do not stimulate FGF23 gene expression in gastrocnemius muscles of Wistar rats. While the low intensity of treadmill exercise does not increase FGF23 relative mRNA expression, moderate and high intensities of treadmill exercise increase FGF23 gene expression in the Wistar rat's soleus muscles

Paper Citation

in Harvard Style

Gunadi J., Jasaputra D., Gunawan D., Edwinanto L., Kwee L., Pramono H., Suhendra A., Sariwidyantry G., Goenawan H. and Lesmana R. (2021). The Effect of Different Intensities of Treadmill Exercise on FGF23 Gene Expression in Gastrocnemius and Soleus Muscles of Wistar Rats. In Proceedings of the 1st International Conference on Emerging Issues in Technology, Engineering and Science - Volume 1: ICE-TES, ISBN 978-989-758-601-9, pages 81-86. DOI: 10.5220/0010744600003113

in Bibtex Style

@conference{ice-tes21,
author={Julia Gunadi and Diana Jasaputra and Decky Gunawan and Ludovicus Edwinanto and Limdawati Kwee and Harijadi Pramono and Adrian Suhendra and Ghita Sariwidyantry and Hanna Goenawan and Ronny Lesmana},
title={The Effect of Different Intensities of Treadmill Exercise on FGF23 Gene Expression in Gastrocnemius and Soleus Muscles of Wistar Rats},
booktitle={Proceedings of the 1st International Conference on Emerging Issues in Technology, Engineering and Science - Volume 1: ICE-TES,},
year={2021},
pages={81-86},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010744600003113},
isbn={978-989-758-601-9},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Emerging Issues in Technology, Engineering and Science - Volume 1: ICE-TES,
TI - The Effect of Different Intensities of Treadmill Exercise on FGF23 Gene Expression in Gastrocnemius and Soleus Muscles of Wistar Rats
SN - 978-989-758-601-9
AU - Gunadi J.
AU - Jasaputra D.
AU - Gunawan D.
AU - Edwinanto L.
AU - Kwee L.
AU - Pramono H.
AU - Suhendra A.
AU - Sariwidyantry G.
AU - Goenawan H.
AU - Lesmana R.
PY - 2021
SP - 81
EP - 86
DO - 10.5220/0010744600003113