Separation Microfluidic Devices Fabricated by Different Milling Processes

Inês M. Gonçalves, Inês M. Gonçalves, Miguel Madureira, Inês M. Gonçalves, Helmut Schütte, Ana S. Moita, Ana S. Moita, Graça Minas, Stefan Gassmann, Rui Lima, Rui Lima

2022

Abstract

The diagnostic of several diseases can be performed by analysing the blood plasma of the patient. Despite of the extensive research work, there is still the need to improve the current low-cost fabrication techniques and devices for the separation of the plasma from the blood cells. Microfluidic biomedical devices have great potential for that process. Hence, two microfluidic devices made by micromilling and sealed with or without the solvent bonding technique were tested by means of a blood analogue fluid. A high-speed video microscopy system was used for the visualization and acquisition of the analogue fluid flow. Then, the separation of particles and plasma was evaluated using the software ImageJ. The device manufactured by the micromilling process without bonding showed a significant reduction of the amount of cells between the entrance and the exit of the microchannels. However, further analysis and optimizations of the microfluidic devices will be conducted in future work.

Paper Citation

in Harvard Style

Gonçalves I., Madureira M., Miranda I., Schütte H., Moita A., Minas G., Gassmann S. and Lima R. (2022). Separation Microfluidic Devices Fabricated by Different Milling Processes. In Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2022) - Volume 1: BIODEVICES; ISBN 978-989-758-552-4, SciTePress, pages 185-190. DOI: 10.5220/0010906500003123

in Bibtex Style

@conference{biodevices22,
author={Inês M. Gonçalves and Miguel Madureira and Inês M. Miranda and Helmut Schütte and Ana S. Moita and Graça Minas and Stefan Gassmann and Rui Lima},
title={Separation Microfluidic Devices Fabricated by Different Milling Processes},
booktitle={Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2022) - Volume 1: BIODEVICES},
year={2022},
pages={185-190},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010906500003123},
isbn={978-989-758-552-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2022) - Volume 1: BIODEVICES
TI - Separation Microfluidic Devices Fabricated by Different Milling Processes
SN - 978-989-758-552-4
AU - Gonçalves I.
AU - Madureira M.
AU - Miranda I.
AU - Schütte H.
AU - Moita A.
AU - Minas G.
AU - Gassmann S.
AU - Lima R.
PY - 2022
SP - 185
EP - 190
DO - 10.5220/0010906500003123
PB - SciTePress