Metabonomics Study on the Mechanism of the Effect of Low Salt on the Liver of Qinghai Lake Naked Carp

Yanfei Wu, Yanfei Wu, Jiang Qu, Yi Liu, Yuxiang Cui, Hongfang Qi, Hong Zhang, Yang Wang, Qingjing Zhang, Qingjing Zhang

2022

Abstract

In order to explore the metabonomics study of the mechanism of low salt on the liver of Qinghai Lake naked carp, this study investigated the liver enzyme activity, tissue structure and related immune genes during the salinity change of Qinghai Lake naked carp. The role of naked carp in immunity can provide a theoretical basis for the research on the adaptability of Qinghai Lake naked carp to changes in salinity. Two experimental groups of Qinghai Lake naked carp with different salinities were established in the Emergency Center (JH) and Qinghai Lake (QH). The rescue center is Freshwater, and the salinity of Qinghai Lake is 1.24‰. This experiment uses ultra-high performance liquid chromatography non-targeted metabonomics technology, and the differential metabolites were screened according to the variable weight value (VIP) and independent sample T test, and the KEGG pathway enrichment and annotation analysis were performed. The results showed that compared with the JH group, in this study, 221 metabolites among the 1,525 differential metabolites identified received 90 KEGG annotations. We performed KEGG enrichment analysis on the 65 differential proteins obtained, and the results showed that the differentially expressed proteins mainly come from primary bile acid biosynthesis: M (Primary bile acid biosynthesis: M), Parkinson’s disease: (Parkinson disease: HD), Linoleic acid metabolism: M (Linoleic acid metabolism: M), protein digestion and absorption: OS (Protein digestion and absorption: OS), cancer choline metabolism: HD (Choline metabolism in cancer: HD) , This study clarified the metabonomics of the liver metabolism mechanism of Qinghai Lake naked carp with different salinities, and the study of Qinghai Lake naked carp liver function has a good guiding significance for molecular biology.

Paper Citation

in Harvard Style

Wu Y., Qu J., Liu Y., Cui Y., Qi H., Zhang H., Wang Y. and Zhang Q. (2022). Metabonomics Study on the Mechanism of the Effect of Low Salt on the Liver of Qinghai Lake Naked Carp. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 225-230. DOI: 10.5220/0011196600003443

in Bibtex Style

@conference{icbeb22,
author={Yanfei Wu and Jiang Qu and Yi Liu and Yuxiang Cui and Hongfang Qi and Hong Zhang and Yang Wang and Qingjing Zhang},
title={Metabonomics Study on the Mechanism of the Effect of Low Salt on the Liver of Qinghai Lake Naked Carp},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={225-230},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011196600003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Metabonomics Study on the Mechanism of the Effect of Low Salt on the Liver of Qinghai Lake Naked Carp
SN - 978-989-758-595-1
AU - Wu Y.
AU - Qu J.
AU - Liu Y.
AU - Cui Y.
AU - Qi H.
AU - Zhang H.
AU - Wang Y.
AU - Zhang Q.
PY - 2022
SP - 225
EP - 230
DO - 10.5220/0011196600003443