Analysis of Possible Ingredient and Manufacture Steps of Oral GLP-1 Receptor Agonists

Zhiyue Lin

2022

Abstract

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) is a efficient medicine treating diabetes 2 and the dosage form are mainly injection. The Rybelsus is the only oral dosage form at current. This paper analyzes the possible ingredient and pharmaceutical techniques for different steps when putting GLP-1RAs into manufacture process like the choose the excipients, granulation and coating. The analysis based on the research on peptide drugs and the assignment regarding the details of Rybelsus. The data involved come from different studies or journal and the assignment published by Novo Nordisk. This paper also analyzes the feature the excipient need to have, the possible advantages and different between the freeze drying, dry granulation and direct compression and sort out the two with greatest possibility to be applied based on the feature of API, the importance of coating for biologics will be stated, the function and feature of the coating will be mentioned and a few common example with good quality will be given.

Paper Citation

in Harvard Style

Lin Z. (2022). Analysis of Possible Ingredient and Manufacture Steps of Oral GLP-1 Receptor Agonists. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 321-326. DOI: 10.5220/0011205700003443

in Bibtex Style

@conference{icbeb22,
author={Zhiyue Lin},
title={Analysis of Possible Ingredient and Manufacture Steps of Oral GLP-1 Receptor Agonists},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={321-326},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011205700003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Analysis of Possible Ingredient and Manufacture Steps of Oral GLP-1 Receptor Agonists
SN - 978-989-758-595-1
AU - Lin Z.
PY - 2022
SP - 321
EP - 326
DO - 10.5220/0011205700003443