Mechanisms of the Toxicity of Chiral Pesticides Dinotefuran Enantiomers on Esiena fetida Earthworm

Yaofang Zhang, Youpu Cheng, Yu Cheng, Yu Cheng, Lijuan Lv, Yanling Xu, Chengling Gao

2022

Abstract

As a promising insecticide, dinotefuran has been commercialized and widely used around the world. In this study, the acute toxicity of Rac-dinotefuran and its two enantiomers on earthworm were estimated by artificial soil method according to the OECD criteria at the individual-tissue-cell-molecule level. The 14d-LC50 values were 2.372 mg/kg for Rac-(±)-dinotefuran, 1.158 mg/kg for S-(+)-Dinotefuran and 6.002 mg/kg for R-(-)-Dinotefuran respectively. E. foetida was exposed to different concentrations of Rac-dinotefuran and its two enantiomers and the enzyme activities, DNA damage and gene expression were measured on 3, 7, 14, 21, and 28 days of post treatments, respectively. The results showed that Rac-dinotefuran and its two enantiomers caused obvious modulations on DNA damage, enzyme activities and gene expression. Additionally, the toxicity of Rac-dinotefuran and its two enantiomers behaved in timedose-dependent manner

Paper Citation

in Harvard Style

Zhang Y., Cheng Y., Cheng Y., Lv L., Xu Y. and Gao C. (2022). Mechanisms of the Toxicity of Chiral Pesticides Dinotefuran Enantiomers on Esiena fetida Earthworm. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 547-552. DOI: 10.5220/0011232400003443

in Bibtex Style

@conference{icbeb22,
author={Yaofang Zhang and Youpu Cheng and Yu Cheng and Lijuan Lv and Yanling Xu and Chengling Gao},
title={Mechanisms of the Toxicity of Chiral Pesticides Dinotefuran Enantiomers on Esiena fetida Earthworm},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={547-552},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011232400003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Mechanisms of the Toxicity of Chiral Pesticides Dinotefuran Enantiomers on Esiena fetida Earthworm
SN - 978-989-758-595-1
AU - Zhang Y.
AU - Cheng Y.
AU - Cheng Y.
AU - Lv L.
AU - Xu Y.
AU - Gao C.
PY - 2022
SP - 547
EP - 552
DO - 10.5220/0011232400003443