Microorganism Coculture-independent Synthesis of Berkeleypenostatin A

Kun Wei

2022

Abstract

In 2021, berkeleypenostatins A-G have been biosynthesized by the coculture fermentation of microbes Penicillium fuscum and P. camembertii/clavigerum - isolated from the Berkeley Pit Lake (Stierle, Stierle, Decato, Alverson, Apedaile, 2021). Tested by the NCI Developmental Therapeutics Program, berkeleypenostatin A effectively inhibited the migration of human pancreatic carcinoma cells (HPAF-II) (Stierle, Stierle, Decato, Alverson, Apedaile, 2021). However, despire the potent anti-tumor activity demonstrated by berkeleypenostatin A, its production from terrestrial extremophilic fungi presents challenges such as low-cell growth and high shear sensitivity (Ludlow, Clark 1991). Considering the potential of berkeleypenostatin A in pancreatic cancer treatment, this report proposes a laboratory synthesis of berkeleypenostatin A as an alternative to fungal coculture. The report analyzes berkeleypenostatin A’s common atoms, deduces its retrosynthesis disconnections, and plans an effective synthesis route. To maximize the convergency of the synthesis, it begins with the reaction between a strong nucleophile and electrophile, proceeds to the McMurry coupling and the Diels-Alder reaction, and ends with the addition of glucose. Such a universal and simple synthesis introduces a series of rapid steps in producing berkeleypenostatin A, a potential anti-cancer material, which offers an innovative insight to the future treatment of pancreatic cancer.

Paper Citation

in Harvard Style

Wei K. (2022). Microorganism Coculture-independent Synthesis of Berkeleypenostatin A. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 797-802. DOI: 10.5220/0011296500003443

in Bibtex Style

@conference{icbeb22,
author={Kun Wei},
title={Microorganism Coculture-independent Synthesis of Berkeleypenostatin A},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={797-802},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011296500003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Microorganism Coculture-independent Synthesis of Berkeleypenostatin A
SN - 978-989-758-595-1
AU - Wei K.
PY - 2022
SP - 797
EP - 802
DO - 10.5220/0011296500003443