Determination of Half-Life in Mutation Process of Polymerase Basic Protein 1 Family from Influenza A Virus

Shaomin Yan, Guang Wu

2022

Abstract

The evolutionary process of a protein family is usually an up and down fluctuating curve when it presents in the x, y coordinates, where the x-axis is time and y-axis is an evolutionary feature of proteins. This irregular curve characterizes its patterns with various periodicities and unexplainable time frames. In the past, we used the fast Fourier transform (FFT) to find these periodicities in hemagglutinin, a surface protein from influenza A virus. However, FFT cannot distinguish the up and down fluctuations without periodicity. In this study, we employ the analytical solution of a system of differential equations from our previous studies to determine the half-life of evolution of the polymerase basic protein 1 (PB1) from influenza A virus from 1918 to 2009. We (i) converted 2352 PB1 into the predictable portion, (ii) presented these predictable portions according to their sampling times with respect to subtypes, (iii) employed the analytical solution to fit the predictable portions versus time profile, (iv) used several statistical measures to determine the goodness-of-fit, and (v) obtained the half-life of evolutions with respect to subtypes. Although our study sheds some insight onto the PB1evolution, much work is needed to better understand the virus evolution.

Paper Citation

in Harvard Style

Yan S. and Wu G. (2022). Determination of Half-Life in Mutation Process of Polymerase Basic Protein 1 Family from Influenza A Virus. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 1051-1056. DOI: 10.5220/0011377200003443

in Bibtex Style

@conference{icbeb22,
author={Shaomin Yan and Guang Wu},
title={Determination of Half-Life in Mutation Process of Polymerase Basic Protein 1 Family from Influenza A Virus},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={1051-1056},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011377200003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Determination of Half-Life in Mutation Process of Polymerase Basic Protein 1 Family from Influenza A Virus
SN - 978-989-758-595-1
AU - Yan S.
AU - Wu G.
PY - 2022
SP - 1051
EP - 1056
DO - 10.5220/0011377200003443