Cisplatin and Its Intercellular Cytotoxicity: Mechanism Derived from Different Pathway and Progression Targeting Toxicity Concern

Minhui Liu, Yingxuan Yuan, Xiuqi Zhang

2022

Abstract

Cisplatin is a metal platinum complex with anticancer activity. It is a cell cycle nonspecific antitumor drug that can produce effective cytotoxicity. It mainly crosslinks with DNA, induces apoptosis, inhibits cell viability and kills tumor cells, and also has a certain effect on RNA and protein of tumor cells. Cisplatin, as a kind of classic anticancer drug, plays an important role in clinical chemotherapy. The emergence of cisplatin resistance is the product of the interaction of multiple mechanisms. In this paper, by consulting the relevant literature on cisplatin in recent years, the paper summarizes cisplatin’s main mechanisms and recent research progresses.

Paper Citation

in Harvard Style

Liu M., Yuan Y. and Zhang X. (2022). Cisplatin and Its Intercellular Cytotoxicity: Mechanism Derived from Different Pathway and Progression Targeting Toxicity Concern. In Proceedings of the 1st International Conference on Food Science and Biotechnology - Volume 1: FSB; ISBN 978-989-758-638-5, SciTePress, pages 80-87. DOI: 10.5220/0012002600003625

in Bibtex Style

@conference{fsb22,
author={Minhui Liu and Yingxuan Yuan and Xiuqi Zhang},
title={Cisplatin and Its Intercellular Cytotoxicity: Mechanism Derived from Different Pathway and Progression Targeting Toxicity Concern},
booktitle={Proceedings of the 1st International Conference on Food Science and Biotechnology - Volume 1: FSB},
year={2022},
pages={80-87},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0012002600003625},
isbn={978-989-758-638-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Food Science and Biotechnology - Volume 1: FSB
TI - Cisplatin and Its Intercellular Cytotoxicity: Mechanism Derived from Different Pathway and Progression Targeting Toxicity Concern
SN - 978-989-758-638-5
AU - Liu M.
AU - Yuan Y.
AU - Zhang X.
PY - 2022
SP - 80
EP - 87
DO - 10.5220/0012002600003625
PB - SciTePress