The Role of SETD2 and VHL in Promoting Renal Fibrosis

Yangtian Yan

2022

Abstract

An excess accumulation of extracellular matrix is involved in renal fibrosis, which usually leads to a loss of function when scar tissues replace normal tissues. This process is stimulated by multiple different pathogenic factors that trigger the cascades of reparation converging in molecular signals responsible for initiating and driving fibrosis. SETD2 and VHL are both tumour suppressor genes, the former acts as an epigenetic modifier that is responsible for trimethylation of H3K36, and the latter works by controlling extracellular matrix formation, apoptosis response, and the epithelial-to-mesenchymal transition. Whether SETD2 and VHL play roles in promoting the occurrence of renal fibrosis is still unknown. Therefore, by creating the mouse model with the specific knockout of VHL and SETD2 genes, our experiment analyses their effects on the kidney tissue. The result indicates that there is an up-regulation for the expression level of inflammation-related genes in the mouse kidney model with both VHL and SETD2 knocked out other than with VHL-KO only, in combination with the HE, Masson, and Sirius Red staining images we performed, we can get a conclusion that these two genes, SETD2 and VHL, can trigger the occurrence of renal fibrosis. These results can provide a solid theoretical basis for the molecular mechanism of action and prospects of relevant drug screening and clinical targeted therapy.

Paper Citation

in Harvard Style

Yan Y. (2022). The Role of SETD2 and VHL in Promoting Renal Fibrosis. In Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB; ISBN 978-989-758-637-8, SciTePress, pages 386-391. DOI: 10.5220/0012021400003633

in Bibtex Style

@conference{icbb22,
author={Yangtian Yan},
title={The Role of SETD2 and VHL in Promoting Renal Fibrosis},
booktitle={Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB},
year={2022},
pages={386-391},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0012021400003633},
isbn={978-989-758-637-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB
TI - The Role of SETD2 and VHL in Promoting Renal Fibrosis
SN - 978-989-758-637-8
AU - Yan Y.
PY - 2022
SP - 386
EP - 391
DO - 10.5220/0012021400003633
PB - SciTePress