Use of Oncolytic Vaccinia Virus Armed with Certain Cytokines (IL-7, IL-12, IL-15, IL-21) in Combination with Checkpoint Inhibitors to Treat Non-Small Cell Lung Cancer

Yuqian Xu, Yuantong Li, Ziyang Yin, Zihao Jin, Wendao Li, Zhaoyang Che

2022

Abstract

A variety of oncolytic viruses (OVs) have been reported in treating different cancers and several have entered clinical trials. This study proposes the combination of cytokines IL-7, IL-12, IL-15, IL-21, and checkpoint inhibitors (CPIs) co-expressed on an oncolytic vaccinia virus JX-594 to treat non-small cell lung cancer (NSCLC) with the aim of tumor regression. The effectiveness of the modified JX-594 vaccinia virus is measured both in H460 cell lines and in LSL-KrasG12D mouse model, including the production of cytokines and CPI, cytotoxicity, tumor growth, overall survival and tumor-infiltrating lymphocytes (TILs). The increased overall survival rate and tumor size regression in mouse model are predicted.

Paper Citation

in Harvard Style

Xu Y., Li Y., Yin Z., Jin Z., Li W. and Che Z. (2022). Use of Oncolytic Vaccinia Virus Armed with Certain Cytokines (IL-7, IL-12, IL-15, IL-21) in Combination with Checkpoint Inhibitors to Treat Non-Small Cell Lung Cancer. In Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB; ISBN 978-989-758-637-8, SciTePress, pages 457-466. DOI: 10.5220/0012032500003633

in Bibtex Style

@conference{icbb22,
author={Yuqian Xu and Yuantong Li and Ziyang Yin and Zihao Jin and Wendao Li and Zhaoyang Che},
title={Use of Oncolytic Vaccinia Virus Armed with Certain Cytokines (IL-7, IL-12, IL-15, IL-21) in Combination with Checkpoint Inhibitors to Treat Non-Small Cell Lung Cancer},
booktitle={Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB},
year={2022},
pages={457-466},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0012032500003633},
isbn={978-989-758-637-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB
TI - Use of Oncolytic Vaccinia Virus Armed with Certain Cytokines (IL-7, IL-12, IL-15, IL-21) in Combination with Checkpoint Inhibitors to Treat Non-Small Cell Lung Cancer
SN - 978-989-758-637-8
AU - Xu Y.
AU - Li Y.
AU - Yin Z.
AU - Jin Z.
AU - Li W.
AU - Che Z.
PY - 2022
SP - 457
EP - 466
DO - 10.5220/0012032500003633
PB - SciTePress