A Formal Probabilistic Model of the Inhibitory Control Circuit in the Brain

Elisabetta De Maria, Benjamin Lapijover, Thibaud L’Yvonnet, Sabine Moisan, Jean-Paul Rigault

2023

Abstract

The decline of inhibitory control efficiency in aging subjects with neurodegenerative diseases is due to anatomical and functional changes in (pre)frontal regions of the brain. Among these regions, the basal ganglia play a central role in the inhibitory control loop. We propose a probabilistic formal model of the biological neural network governing the inhibitory control function and we study some of its relevant dynamic properties. We also explore how parameter variations influence the probability for the model to display some key behaviors. We model the different structures of the inhibitory control loop thanks to discrete Markov chains representing Leaky Integrate and Fire neurons. The model is implemented and verified using the P RISM framework. The final aim is to detect sources of pathological behaviors in the neural network responsible for inhibitory control.

Paper Citation

in Harvard Style

De Maria E., Lapijover B., L’Yvonnet T., Moisan S. and Rigault J. (2023). A Formal Probabilistic Model of the Inhibitory Control Circuit in the Brain. In Proceedings of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2023) - Volume 3: BIOINFORMATICS; ISBN 978-989-758-631-6, SciTePress, pages 146-154. DOI: 10.5220/0011625700003414

in Bibtex Style

@conference{bioinformatics23,
author={Elisabetta De Maria and Benjamin Lapijover and Thibaud L’Yvonnet and Sabine Moisan and Jean-Paul Rigault},
title={A Formal Probabilistic Model of the Inhibitory Control Circuit in the Brain},
booktitle={Proceedings of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2023) - Volume 3: BIOINFORMATICS},
year={2023},
pages={146-154},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011625700003414},
isbn={978-989-758-631-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2023) - Volume 3: BIOINFORMATICS
TI - A Formal Probabilistic Model of the Inhibitory Control Circuit in the Brain
SN - 978-989-758-631-6
AU - De Maria E.
AU - Lapijover B.
AU - L’Yvonnet T.
AU - Moisan S.
AU - Rigault J.
PY - 2023
SP - 146
EP - 154
DO - 10.5220/0011625700003414
PB - SciTePress