Hemodynamics of Convergent Cavopulmonary Connection with Ventricular Assist Device for Fontan Surgery: A Computational and Experimental Study

Qiyuan Wu, Vincent Cleveland, Seda Aslan, Xiaolong Liu, Jacqueline Contento, Paige Mass, Byeol Kim, Catherine Pollard, Pranava Sinha, Yue-Hin Loke, Yue-Hin Loke, Laura Olivieri, Laura Olivieri, Axel Krieger

2023

Abstract

Fontan surgery is the clinical standard for single ventricle heart disease, with total cavopulmonary connection (TCPC) as the current preferred configuration. Mechanical circulatory support (MCS) is often desired to improve hemodynamics and reduce post-surgical complications. Convergent cavopulmonary connection (CCPC) was recently proposed to solve the difficulty of integrating MCS in TCPC. In this study, we investigated the hemodynamics of the CCPC conduit with a ventricular assist device (VAD) integrated and explored indexed power jump (iPJ) and time-averaged wall shear stress (TAWSS) by computational fluid dynamics (CFD) with assistance from flow loop experiments. Positive time-averaged iPJ was observed in the cases with limited cardiac output, and regions with non-physiologic low TAWSS were significantly reduced for all cases. These results could strengthen the feasibility of this novel CCPC Fontan configuration as a solution for MCS integration.

Paper Citation

in Harvard Style

Wu Q., Cleveland V., Aslan S., Liu X., Contento J., Mass P., Kim B., Pollard C., Sinha P., Loke Y., Olivieri L. and Krieger A. (2023). Hemodynamics of Convergent Cavopulmonary Connection with Ventricular Assist Device for Fontan Surgery: A Computational and Experimental Study. In Proceedings of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2023) - Volume 3: BIOINFORMATICS; ISBN 978-989-758-631-6, SciTePress, pages 51-58. DOI: 10.5220/0011633200003414

in Bibtex Style

@conference{bioinformatics23,
author={Qiyuan Wu and Vincent Cleveland and Seda Aslan and Xiaolong Liu and Jacqueline Contento and Paige Mass and Byeol Kim and Catherine Pollard and Pranava Sinha and Yue-Hin Loke and Laura Olivieri and Axel Krieger},
title={Hemodynamics of Convergent Cavopulmonary Connection with Ventricular Assist Device for Fontan Surgery: A Computational and Experimental Study},
booktitle={Proceedings of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2023) - Volume 3: BIOINFORMATICS},
year={2023},
pages={51-58},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011633200003414},
isbn={978-989-758-631-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2023) - Volume 3: BIOINFORMATICS
TI - Hemodynamics of Convergent Cavopulmonary Connection with Ventricular Assist Device for Fontan Surgery: A Computational and Experimental Study
SN - 978-989-758-631-6
AU - Wu Q.
AU - Cleveland V.
AU - Aslan S.
AU - Liu X.
AU - Contento J.
AU - Mass P.
AU - Kim B.
AU - Pollard C.
AU - Sinha P.
AU - Loke Y.
AU - Olivieri L.
AU - Krieger A.
PY - 2023
SP - 51
EP - 58
DO - 10.5220/0011633200003414
PB - SciTePress