The Antidiabetic Effect of Black Glutinous Tapai Beverage in Metabolic Syndrome Rats

Rahmi Khoirunnisa, Wachid Putranto, Ida Nurwati

2023

Abstract

Metabolic syndrome (MetS) known as insulin resistance syndrome, is recognized as a risk factor for type 2 diabetes mellitus. Management of MetS involves a combination of lifestyle changes and pharmacological interventions. Black glutinous tapai beverage (BGTB) as local food contains Lactobacillus spp., which can be a potential source of probiotics to improve hyperglycemia. This study aimed to determine the efficacy of BGTB as an antidiabetic in rat models of MetS. This study used 30 male Sprague Dawley rats which were divided into five groups, one as a normal group (N) given a standard diet, and the other four groups were given a high-fat diet for 2 weeks and induced by Streptozotocin (STZ) and Nicotinamide (NA), i.e. negative control (KN) was given a standard diet, positive control (KP) was given metformin 9 mg, treatment 1 (P1) and treatment 2 (P2) were given BGTB 0,9 ml 200 gr-1 rat BW and 1,8 ml 200 gr-1 rat BW, respectively for four weeks. The result showed a significant difference (p=0.000) in blood glucose and HbA1c after giving BGTB. This study showed that BGTB has the potential to be developed as a functional beverage and source of probiotics for people with MetS.

Paper Citation

in Harvard Style

Khoirunnisa R., Putranto W. and Nurwati I. (2023). The Antidiabetic Effect of Black Glutinous Tapai Beverage in Metabolic Syndrome Rats. In Proceedings of the 5th International Conference on Social Determinants of Health - Volume 1: ICSDH; ISBN 978-989-758-727-6, SciTePress, pages 75-81. DOI: 10.5220/0012900900004564

in Bibtex Style

@conference{icsdh23,
author={Rahmi Khoirunnisa and Wachid Putranto and Ida Nurwati},
title={The Antidiabetic Effect of Black Glutinous Tapai Beverage in Metabolic Syndrome Rats},
booktitle={Proceedings of the 5th International Conference on Social Determinants of Health - Volume 1: ICSDH},
year={2023},
pages={75-81},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0012900900004564},
isbn={978-989-758-727-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 5th International Conference on Social Determinants of Health - Volume 1: ICSDH
TI - The Antidiabetic Effect of Black Glutinous Tapai Beverage in Metabolic Syndrome Rats
SN - 978-989-758-727-6
AU - Khoirunnisa R.
AU - Putranto W.
AU - Nurwati I.
PY - 2023
SP - 75
EP - 81
DO - 10.5220/0012900900004564
PB - SciTePress