Developing a Head-Attached Interface Device for Closed-Loop Transcranial Ultrasound Stimulation in the Mouse Brain

Ryo Furukawa, Shuichi Murakami, Takashi Tateno

2025

Abstract

Transcranial ultrasound stimulation (TUS), which can be used to noninvasively stimulate local and deep brain areas, holds significant promise for clinical applications. However, TUS apparatus is typically constructed with several components, including a relatively large single-element ultrasound (US) transducer, a waveguide, and a driving source. These components pose challenges when conducting experiments with freely moving small animals, especially in the context of wearable devices. Additionally, conventional open-loop stimulation systems do not allow for the simultaneous monitoring of neural activity, which can sometimes result in the overactivation of neural responses. In this study, we developed a head-mounted piezoelectric micromachined ultrasound transducer (PMUT) array with integrated monitoring electrodes to serve as a TUS interface for mice. To determine effective array patterns for optimal US beam profiles, we first conducted beamforming simulations. We then microfabricated the PMUT arrays according to the results of these simulations. Subsequently, we performed electroencephalographic (EEG) recordings to evaluate the potential of TUS in mice while simultaneously monitoring neural activities. Finally, we discuss future applications of a closed-loop TUS system in the treatment of brain diseases.

Paper Citation

in Harvard Style

Furukawa R., Murakami S. and Tateno T. (2025). Developing a Head-Attached Interface Device for Closed-Loop Transcranial Ultrasound Stimulation in the Mouse Brain. In Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES; ISBN 978-989-758-731-3, SciTePress, pages 17-25. DOI: 10.5220/0013082900003911

in Bibtex Style

@conference{biodevices25,
author={Ryo Furukawa and Shuichi Murakami and Takashi Tateno},
title={Developing a Head-Attached Interface Device for Closed-Loop Transcranial Ultrasound Stimulation in the Mouse Brain},
booktitle={Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES},
year={2025},
pages={17-25},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0013082900003911},
isbn={978-989-758-731-3},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES
TI - Developing a Head-Attached Interface Device for Closed-Loop Transcranial Ultrasound Stimulation in the Mouse Brain
SN - 978-989-758-731-3
AU - Furukawa R.
AU - Murakami S.
AU - Tateno T.
PY - 2025
SP - 17
EP - 25
DO - 10.5220/0013082900003911
PB - SciTePress