Modeling HIF-ILK Interaction Using Continuous Petri Nets

Viktor Gilin, Sanne Laauwen, Yuying Xia, Noria Yousufi, Lu Cao

2025

Abstract

Oxygen concentration in tumor micro-environment is a well-established signal that can induce aggressive cancer behaviour. In particular, low oxygen levels (hypoxia) activate the Hypoxia-Inducible Factor(HIF) pathway which has an array of target systems. One of these systems is Integrin-Linked Kinase (ILK) pathway, which influences key signaling pathways for cell survival, proliferation, and migration. Hence, this paper aimed to explore the interconnection between these two pathways. Using the Petri net modeling tool Snoopy, an established HIF network model was transformed to be a continuous Petri net. Subsequently, the network was expanded to incorporate a feedback element from the ILK pathway to HIF, based on gene expression data. The resulting model conserved the oxygen switch response of the original HIF model and positively amplified HIF’s output. Therefore, this model provides a starting point for establishing a system reflecting crucial effect on hypoxia-induced cancer behavior, and could potentially serve as a basis for future drug development.

Paper Citation

in Harvard Style

Gilin V., Laauwen S., Xia Y., Yousufi N. and Cao L. (2025). Modeling HIF-ILK Interaction Using Continuous Petri Nets. In Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOINFORMATICS; ISBN 978-989-758-731-3, SciTePress, pages 537-544. DOI: 10.5220/0013102600003911

in Bibtex Style

@conference{bioinformatics25,
author={Viktor Gilin and Sanne Laauwen and Yuying Xia and Noria Yousufi and Lu Cao},
title={Modeling HIF-ILK Interaction Using Continuous Petri Nets},
booktitle={Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOINFORMATICS},
year={2025},
pages={537-544},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0013102600003911},
isbn={978-989-758-731-3},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOINFORMATICS
TI - Modeling HIF-ILK Interaction Using Continuous Petri Nets
SN - 978-989-758-731-3
AU - Gilin V.
AU - Laauwen S.
AU - Xia Y.
AU - Yousufi N.
AU - Cao L.
PY - 2025
SP - 537
EP - 544
DO - 10.5220/0013102600003911
PB - SciTePress