A Low-Noise Amplifier in Submicron CMOS for Neural Recording on Optogenetics Applications

H. E. Oshiro, H. E. Oshiro, R. A. P. Andrade, J. N. S. Junior, M. Luppe, E. Colombari, M. C. Dias, J. P. Carmo

2025

Abstract

Optogenetics combines optical and genetic techniques to control and monitor neuronal activities. Recent efforts seek the development of portable and even wireless electronics for optical activation and acquisition of biopotentials, aiming to offer greater mobility and freedom to study animals, in contrast to the large equipment commonly found in laboratories that perform the activation of lasers, signal amplifiers and acquisition. In this context, this paper reports on the design and simulation of a low-noise amplifier (LNA) to acquire neural signals on optogenetics applications. The simulations showed that with the nominal voltage supply of 1.8V this LNA is able to amplify neuronal signals in the range of 0.3Hz up to 172kHz with a gain of 39.3dB, while rejecting DC offsets generated at the interface between the electrodes. The simulations also showed that with variations of 20% with relation to the nominal voltage supply, the worse cases of the lower and higher cut-off frequencies were 0.3Hz (increased) and 51.3kHz (decreased), respectively. Moreover, under these stressing conditions the gain had a variation between 36.8dB for the worst scenario and 40dB for the best scenario. These results are more than enough to meet the bandwidth requirements on optogenetics and it can be concluded that the specifications of the LNA are not affected by the useful life of batteries under the aforementioned voltage variation range. The power consumption of the system is around 64μW from a 1.8V voltage supply. This LNA was designed in the 6 metals/1 poly 0.18m CMOS process from UMC (United Microelectronics Corporation) and occupies an area of 0.092mm2.

Paper Citation

in Harvard Style

Oshiro H., Andrade R., S. Junior J., Luppe M., Colombari E., Dias M. and Carmo J. (2025). A Low-Noise Amplifier in Submicron CMOS for Neural Recording on Optogenetics Applications. In Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: EM4Health; ISBN 978-989-758-731-3, SciTePress, pages 1080-1084. DOI: 10.5220/0013147200003911

in Bibtex Style

@conference{em4health25,
author={H. Oshiro and R. Andrade and J. S. Junior and M. Luppe and E. Colombari and M. Dias and J. Carmo},
title={A Low-Noise Amplifier in Submicron CMOS for Neural Recording on Optogenetics Applications},
booktitle={Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: EM4Health},
year={2025},
pages={1080-1084},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0013147200003911},
isbn={978-989-758-731-3},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: EM4Health
TI - A Low-Noise Amplifier in Submicron CMOS for Neural Recording on Optogenetics Applications
SN - 978-989-758-731-3
AU - Oshiro H.
AU - Andrade R.
AU - S. Junior J.
AU - Luppe M.
AU - Colombari E.
AU - Dias M.
AU - Carmo J.
PY - 2025
SP - 1080
EP - 1084
DO - 10.5220/0013147200003911
PB - SciTePress