Comparative Analysis of Generalized Multiscale Entropy Methods for Coarse-Grained Time Series Construction in Assessing Autonomic Balance in Peripheral Arterial Disease Patients

O. Barquero-Pérez, R. Goya-Esteban, E. Sarabia-Cachadiña, J. Naranjo-Orellana

2025

Abstract

Peripheral Arterial Disease (PAD) is a chronic condition that significantly impacts autonomic balance, as reflected in Heart Rate Variability (HRV). However, the characterization of autonomic balance in PAD patients using HRV is still unclear. Generalized Multiscale Entropy (GMSE) is a nonlinear method capable of characterizing the complexity of HRV across multiple time scales, offering a more nuanced understanding of autonomic dysfunction in PAD patients. 14 healthy male subjects (60±5 years) and 14 male intermittent claudication patients (64±6 years) underwent 10 minutes of ECG recording from which RR interval time series were obtained. This study provides a comparative analysis of different GMSE methods for constructing coarse-grained time series, specifically using the mean, mean absolute deviation (MAD), standard deviation (σ), and variance (σ2) approaches. By applying these methods, we investigate their efficacy in differentiating between healthy individuals and PAD patients. Our results demonstrate that the variance coarse-grained method offers superior discriminatory power, revealing statistically significant differences. These findings suggest that the variance-based GMSE method is the most effective approach for assessing autonomic imbalance in PAD patients, with potential applications in improving diagnostic tools and treatment strategies.

Paper Citation

in Bibtex Style

@conference{biosignals25,
author={O. Barquero-Pérez and R. Goya-Esteban and E. Sarabia-Cachadiña and J. Naranjo-Orellana},
title={Comparative Analysis of Generalized Multiscale Entropy Methods for Coarse-Grained Time Series Construction in Assessing Autonomic Balance in Peripheral Arterial Disease Patients},
booktitle={Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOSIGNALS},
year={2025},
pages={893-898},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0013165000003911},
isbn={978-989-758-731-3},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOSIGNALS
TI - Comparative Analysis of Generalized Multiscale Entropy Methods for Coarse-Grained Time Series Construction in Assessing Autonomic Balance in Peripheral Arterial Disease Patients
SN - 978-989-758-731-3
AU - Barquero-Pérez O.
AU - Goya-Esteban R.
AU - Sarabia-Cachadiña E.
AU - Naranjo-Orellana J.
PY - 2025
SP - 893
EP - 898
DO - 10.5220/0013165000003911
PB - SciTePress

in Harvard Style

Barquero-Pérez O., Goya-Esteban R., Sarabia-Cachadiña E. and Naranjo-Orellana J. (2025). Comparative Analysis of Generalized Multiscale Entropy Methods for Coarse-Grained Time Series Construction in Assessing Autonomic Balance in Peripheral Arterial Disease Patients. In Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOSIGNALS; ISBN 978-989-758-731-3, SciTePress, pages 893-898. DOI: 10.5220/0013165000003911