A Conceptual Model-Based Application for the Treatment and Management of Data in Pediatric Oncology: The Neuroblastoma Use Case

Jesús Carreño-Bolufer, José Fabián Reyes Román, Sergio Pérez Andrés, Désirée Ramal Pons, Víctor Juárez Vidal, Adela Cañete Nieto, Óscar Pastor

2025

Abstract

Neuroblastoma is one of the leading causes of death in childhood oncology. Current treatments for these patients are general and not targeted, including radiotherapy, chemotherapy, and surgery. There is a need for more efficient methods. Precision Medicine (PM) can help to overcome this challenge. PM incorporates clinical, lifestyle, and genomic data, among others, into a standardized process to provide individualized treatment. However, a large amount of data is needed to achieve PM, and the heterogeneity present in the case of neuroblastoma poses a challenge for integration and, consequently, for knowledge generation. We need a solid domain definition that provides a foundation for experts to work on, which implies generating a conceptual model. Based on this model, any Information System (IS) can be developed. ISs play a vital role in managing clinical data efficiently. Much of the clinical data has been captured and managed over the years with inefficient tools such as spreadsheets. In this work, we first present the new Conceptual Model of Neuroblastoma (CMN), with a special focus on genomics, and second, ClinGenNBL, a conceptual model-based web application that implement the CMN with the goal of assisting clinicians in managing patients with neuroblastoma through a user-friendly interface.

Paper Citation

in Harvard Style

Carreño-Bolufer J., Reyes Román J., Pérez Andrés S., Ramal Pons D., Juárez Vidal V., Cañete Nieto A. and Pastor Ó. (2025). A Conceptual Model-Based Application for the Treatment and Management of Data in Pediatric Oncology: The Neuroblastoma Use Case. In Proceedings of the 20th International Conference on Evaluation of Novel Approaches to Software Engineering - Volume 1: ENASE; ISBN 978-989-758-742-9, SciTePress, pages 15-26. DOI: 10.5220/0013202600003928

in Bibtex Style

@conference{enase25,
author={Jesús Carreño-Bolufer and José Reyes Román and Sergio Pérez Andrés and Désirée Ramal Pons and Víctor Juárez Vidal and Adela Cañete Nieto and Óscar Pastor},
title={A Conceptual Model-Based Application for the Treatment and Management of Data in Pediatric Oncology: The Neuroblastoma Use Case},
booktitle={Proceedings of the 20th International Conference on Evaluation of Novel Approaches to Software Engineering - Volume 1: ENASE},
year={2025},
pages={15-26},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0013202600003928},
isbn={978-989-758-742-9},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 20th International Conference on Evaluation of Novel Approaches to Software Engineering - Volume 1: ENASE
TI - A Conceptual Model-Based Application for the Treatment and Management of Data in Pediatric Oncology: The Neuroblastoma Use Case
SN - 978-989-758-742-9
AU - Carreño-Bolufer J.
AU - Reyes Román J.
AU - Pérez Andrés S.
AU - Ramal Pons D.
AU - Juárez Vidal V.
AU - Cañete Nieto A.
AU - Pastor Ó.
PY - 2025
SP - 15
EP - 26
DO - 10.5220/0013202600003928
PB - SciTePress