Sweat Quantification During Electrodermal Analysis Combining Paper-Based Microfluidics with Printable Electrodes: Design and Materials

Batoul Hosseinzadeh, Sarah Tonello, Nicola Francesco Lopomo, Emilio Sardini

2025

Abstract

Significant challenges in Electrodermal Activity (EDA) are represented by poor wearability of commercial electrodes and imprecise differentiation between alterations in skin conductivity due to nervous system activities or sweat secretion in response to other stimuli. In this light, we propose a device that combines paper-based microfluidic with printable electrodes to monitor EDA and sweat rate/volume simultaneously. This setup not only refines wearability by implementing flexible, skin-compatible materials but also improves quantification accuracy by distinguishing between baseline EDA conductivity and actual sweat output providing a higher perception of the physiological state by harmonized sweat and EDA data. The preliminary analysis reported was performed in a laboratory environment aiming at two main objectives: i) optimize the design of paper-microfluidics pattern ii) compare different printable inks to select the most suitable one to minimize contact impedance and achieve a sensitivity comparable to standard EDA electrodes. Results obtained suggested the use of thick teeth design of microfluidics geometry to reduce variability in measurements and Poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) as an optimal coating material to provide superior sensitivity (3.07 μS/μl) and repeatability (average Relative Standard Deviation (RSD) of 15%,) with a linearity range of 0-50 µl range while preserving low contact impedance and trustworthy signals.

Paper Citation

in Harvard Style

Hosseinzadeh B., Tonello S., Lopomo N. and Sardini E. (2025). Sweat Quantification During Electrodermal Analysis Combining Paper-Based Microfluidics with Printable Electrodes: Design and Materials. In Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES; ISBN 978-989-758-731-3, SciTePress, pages 65-73. DOI: 10.5220/0013235900003911

in Bibtex Style

@conference{biodevices25,
author={Batoul Hosseinzadeh and Sarah Tonello and Nicola Lopomo and Emilio Sardini},
title={Sweat Quantification During Electrodermal Analysis Combining Paper-Based Microfluidics with Printable Electrodes: Design and Materials},
booktitle={Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES},
year={2025},
pages={65-73},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0013235900003911},
isbn={978-989-758-731-3},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES
TI - Sweat Quantification During Electrodermal Analysis Combining Paper-Based Microfluidics with Printable Electrodes: Design and Materials
SN - 978-989-758-731-3
AU - Hosseinzadeh B.
AU - Tonello S.
AU - Lopomo N.
AU - Sardini E.
PY - 2025
SP - 65
EP - 73
DO - 10.5220/0013235900003911
PB - SciTePress