Modulating Cerebral Rhythms in Parkinson's Disease: Insights on the Role of Auditory Stimulation

Pablo García-Peña, Juan M. López, Milagros Ramos, Milagros Ramos, Milagros Ramos, Daniel González-Nieto, Daniel González-Nieto, Daniel González-Nieto, Guillermo de Arcas, Guillermo de Arcas, Guillermo de Arcas

2025

Abstract

Parkinson's disease (PD) is a neurodegenerative disease characterized by a slowing of brain rhythms, leading to cognitive and motor deficits. Auditory stimulation (AS) has proven to have great potential as a non-invasive approach to modulate brain activity. Nevertheless, despite promising clinical and preclinical findings, optimal AS parameters for its use in PD remain unclear. To investigate the potential therapeutic effects of AS in PD, we aimed to establish an optimal preclinical model and stimulation protocol. Two mouse strains were compared, CD1 and C57BL/6, and assessed their auditory sensitivity. 3-months C57BL/6 mice was selected as the most suitable model for auditory studies. Two literature-based AS protocols were applied, a 10 kHz carrier tone modulated with 40 Hz pulses and a 40 Hz amplitude-modulated tone. Our results demonstrate that comparing pre- and post-stimulation periods, the 10 kHz/40 Hz protocol consistently induced a reduction in delta power and an increase in gamma relative power, with persistent effects of the latter 24 hours post-stimulation. These findings suggest that this specific AS protocol holds promise for targeting abnormal brain rhythms associated with PD and may have potential therapeutic implications. Further research is needed to explore the underlying mechanisms and optimize AS parameters for clinical translation.

Paper Citation

in Harvard Style

García-Peña P., López J., Ramos M., González-Nieto D. and de Arcas G. (2025). Modulating Cerebral Rhythms in Parkinson's Disease: Insights on the Role of Auditory Stimulation. In Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOSIGNALS; ISBN 978-989-758-731-3, SciTePress, pages 752-762. DOI: 10.5220/0013247800003911

in Bibtex Style

@conference{biosignals25,
author={Pablo García-Peña and Juan López and Milagros Ramos and Daniel González-Nieto and Guillermo de Arcas},
title={Modulating Cerebral Rhythms in Parkinson's Disease: Insights on the Role of Auditory Stimulation},
booktitle={Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOSIGNALS},
year={2025},
pages={752-762},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0013247800003911},
isbn={978-989-758-731-3},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOSIGNALS
TI - Modulating Cerebral Rhythms in Parkinson's Disease: Insights on the Role of Auditory Stimulation
SN - 978-989-758-731-3
AU - García-Peña P.
AU - López J.
AU - Ramos M.
AU - González-Nieto D.
AU - de Arcas G.
PY - 2025
SP - 752
EP - 762
DO - 10.5220/0013247800003911
PB - SciTePress